On modelling of immune memory mechanisms

E. Ahmed, A. H. Hashish

Research output: Contribution to journalArticlepeer-review


In human body, the acquired protection against illness is a biological property known as immunological memory. Different mechanisms for immunological memory are proposed and modeled. The first mechanism is the persisting antigen (Ag) where parts of the Ag are anticipated to persist on some Ag presenting cells. A novel application of the Hsu et al.’s model allows stable low Ag density equilibrium state. This state will correspond to the persisting Ag mechanism for the immune memory. The second is idiotypic and extremal mechanisms where mathematical models showed that a memory state could arise in this case. Finally, a simple model is given which shows that competition between effectors may contribute to the memory state.

Original languageEnglish
Pages (from-to)339-342
Number of pages4
JournalTheory in Biosciences
Issue number4
Publication statusPublished - Dec 2003


  • Extremal dynamics
  • Immune memory
  • Mathematical Models

ASJC Scopus subject areas

  • Statistics and Probability
  • Ecology, Evolution, Behavior and Systematics
  • Applied Mathematics


Dive into the research topics of 'On modelling of immune memory mechanisms'. Together they form a unique fingerprint.

Cite this