TY - JOUR
T1 - One-pot hydroacetylation of menadione (vitamin K 3) to menadiol diacetate (vitamin K 4) by heterogeneous catalysis
AU - Dobrinescu, Claudiu
AU - Iorgulescu, Elena E.
AU - Mihailciuc, Constantin
AU - MacOvei, Dan
AU - Wuttke, Stefan
AU - Kemnitz, Erhard
AU - Parvulescu, Vasile I.
AU - Coman, Simona M.
PY - 2012/5/7
Y1 - 2012/5/7
N2 - Vitamin K 4 (menadiol diacetate, MDD) can be easily synthesized through cleaner and more efficient catalytic alternatives following the green chemistry principles. Ionic gold-based hydroxylated fluorides are active bi-functional catalysts for the one-pot hydroacetylation of menadione leading to MDD with 77% selectivity. Unprecedent results were obtained in the presence of oxide-fluoride catalysts by using a microwave-assisted hydrogen-transfer (Meerwein-Ponndorf-Verley reaction) coupled with an acetylation approach, yielding very high selectivities for the target product (95%).
AB - Vitamin K 4 (menadiol diacetate, MDD) can be easily synthesized through cleaner and more efficient catalytic alternatives following the green chemistry principles. Ionic gold-based hydroxylated fluorides are active bi-functional catalysts for the one-pot hydroacetylation of menadione leading to MDD with 77% selectivity. Unprecedent results were obtained in the presence of oxide-fluoride catalysts by using a microwave-assisted hydrogen-transfer (Meerwein-Ponndorf-Verley reaction) coupled with an acetylation approach, yielding very high selectivities for the target product (95%).
KW - hydroxylated fluorides
KW - ionic gold catalyst
KW - microwaves
KW - oxide-fluorides
KW - vitamin k
UR - https://www.scopus.com/pages/publications/84860740759
UR - https://www.scopus.com/pages/publications/84860740759#tab=citedBy
U2 - 10.1002/adsc.201100718
DO - 10.1002/adsc.201100718
M3 - Article
AN - SCOPUS:84860740759
SN - 1615-4150
VL - 354
SP - 1301
EP - 1306
JO - Advanced Synthesis and Catalysis
JF - Advanced Synthesis and Catalysis
IS - 7
ER -