Ontogeny of a novel pituitary protein (7B2) in the human fetal intestine

H. Suzuki; N. D. Christofides; T. E. Adrian; M. Chretien; N. G. Seidah; J. M. Polak; S. R. Bloom

doi:10.1016/0167-0115(85)90172-7

Ontogeny of a novel pituitary protein (7B2) in the human fetal intestine

H. Suzuki, N. D. Christofides, T. E. Adrian, M. Chretien, N. G. Seidah, J. M. Polak, S. R. Bloom

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The developmental profile of the concentration of a novel pituitary protein (7B2) was studied immunochemically in the human gastrointestinal tract from 12 weeks of gestation to 4 months after birth and was compared to the distribution in the adult. 7B2-like immunoreactivity (IR-7B2) was detected in all segments studied, but no gross changes were seen through fetal life. At term higher concentrations of IR-7B2 were found in the duodenum and the antrum, which is similar to the distribution of adult man. Gel permeation chromatography revealed that the main peak of 7B2 immunoreactivity in the fetal intestinal extract eluted with a K_av of 0.3. Similar elution profiles were also observed in extracts of human adult intestine.

Original language	English
Pages (from-to)	289-296
Number of pages	8
Journal	Regulatory Peptides
Volume	12
Issue number	4
DOIs	https://doi.org/10.1016/0167-0115(85)90172-7
Publication status	Published - Nov 28 1985
Externally published	Yes

Keywords

7B2
gastrointestinal tract
ontogeny
radioimmunoassay

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Clinical Biochemistry
Cellular and Molecular Neuroscience

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10.1016/0167-0115(85)90172-7

Cite this

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title = "Ontogeny of a novel pituitary protein (7B2) in the human fetal intestine",

abstract = "The developmental profile of the concentration of a novel pituitary protein (7B2) was studied immunochemically in the human gastrointestinal tract from 12 weeks of gestation to 4 months after birth and was compared to the distribution in the adult. 7B2-like immunoreactivity (IR-7B2) was detected in all segments studied, but no gross changes were seen through fetal life. At term higher concentrations of IR-7B2 were found in the duodenum and the antrum, which is similar to the distribution of adult man. Gel permeation chromatography revealed that the main peak of 7B2 immunoreactivity in the fetal intestinal extract eluted with a Kav of 0.3. Similar elution profiles were also observed in extracts of human adult intestine.",

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AU - Suzuki, H.

AU - Christofides, N. D.

AU - Adrian, T. E.

AU - Chretien, M.

AU - Seidah, N. G.

AU - Polak, J. M.

AU - Bloom, S. R.

PY - 1985/11/28

Y1 - 1985/11/28

N2 - The developmental profile of the concentration of a novel pituitary protein (7B2) was studied immunochemically in the human gastrointestinal tract from 12 weeks of gestation to 4 months after birth and was compared to the distribution in the adult. 7B2-like immunoreactivity (IR-7B2) was detected in all segments studied, but no gross changes were seen through fetal life. At term higher concentrations of IR-7B2 were found in the duodenum and the antrum, which is similar to the distribution of adult man. Gel permeation chromatography revealed that the main peak of 7B2 immunoreactivity in the fetal intestinal extract eluted with a Kav of 0.3. Similar elution profiles were also observed in extracts of human adult intestine.

AB - The developmental profile of the concentration of a novel pituitary protein (7B2) was studied immunochemically in the human gastrointestinal tract from 12 weeks of gestation to 4 months after birth and was compared to the distribution in the adult. 7B2-like immunoreactivity (IR-7B2) was detected in all segments studied, but no gross changes were seen through fetal life. At term higher concentrations of IR-7B2 were found in the duodenum and the antrum, which is similar to the distribution of adult man. Gel permeation chromatography revealed that the main peak of 7B2 immunoreactivity in the fetal intestinal extract eluted with a Kav of 0.3. Similar elution profiles were also observed in extracts of human adult intestine.

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KW - ontogeny

KW - radioimmunoassay

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Ontogeny of a novel pituitary protein (7B2) in the human fetal intestine

Abstract

Keywords

ASJC Scopus subject areas

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