P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretion

Anna Goc; Ahmad Al-Azayzih; Maha Abdalla; Belal Al-Husein; Sravankumar Kavuri; Jeffrey Lee; Kelvin Moses; Payaningal R. Somanath

doi:10.1074/jbc.M112.424770

P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretion

Anna Goc
, Ahmad Al-Azayzih
, Maha Abdalla
, Belal Al-Husein
, Sravankumar Kavuri
, Jeffrey Lee
, Kelvin Moses
, Payaningal R. Somanath

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

Background: The significance of Pak1 in prostate cancer remains unclear. Results: Pak1 knockdown impaired prostate tumor growth via increased expression of TGFβ and reduced secretion of MMP9. Conclusions: We demonstrated that Pak1 is a more potent mediator of prostate cancer cell migration and tumor growth than Pak6, the predominant isoform in the prostate. Significance: A novel role of Pak1 in prostate cancer is identified.

Original language	English
Pages (from-to)	3025-3035
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	5
DOIs	https://doi.org/10.1074/jbc.M112.424770
Publication status	Published - Feb 1 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M112.424770

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Goc, A., Al-Azayzih, A., Abdalla, M., Al-Husein, B., Kavuri, S., Lee, J., Moses, K., & Somanath, P. R. (2013). P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretion. Journal of Biological Chemistry, 288(5), 3025-3035. https://doi.org/10.1074/jbc.M112.424770

P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretion. / Goc, Anna; Al-Azayzih, Ahmad; Abdalla, Maha et al.
In: Journal of Biological Chemistry, Vol. 288, No. 5, 01.02.2013, p. 3025-3035.

Research output: Contribution to journal › Article › peer-review

Goc, A, Al-Azayzih, A, Abdalla, M, Al-Husein, B, Kavuri, S, Lee, J, Moses, K & Somanath, PR 2013, 'P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretion', Journal of Biological Chemistry, vol. 288, no. 5, pp. 3025-3035. https://doi.org/10.1074/jbc.M112.424770

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abstract = "Background: The significance of Pak1 in prostate cancer remains unclear. Results: Pak1 knockdown impaired prostate tumor growth via increased expression of TGFβ and reduced secretion of MMP9. Conclusions: We demonstrated that Pak1 is a more potent mediator of prostate cancer cell migration and tumor growth than Pak6, the predominant isoform in the prostate. Significance: A novel role of Pak1 in prostate cancer is identified.",

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AU - Goc, Anna

AU - Al-Azayzih, Ahmad

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AU - Al-Husein, Belal

AU - Kavuri, Sravankumar

AU - Lee, Jeffrey

AU - Moses, Kelvin

AU - Somanath, Payaningal R.

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P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretion

Abstract

ASJC Scopus subject areas

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