Abstract
The release of pancreatic polypeptide (PP) by gut hormones, acetyl choline and adrenaline was investigated in an isolated perfused pancreas preparation. PP was potently released by 1 nmol/l caerulein (186±12%, p<0.001) and gastric inhibitory peptide (GIP) (211±31%, p<0.005) as well as by 1 [νmol/l acetyl choline (1097±59%, p<0.001). A significant two-fold release of PP was also evoked by 1 nmol/l vasoactive intestinal peptide (VIP) (129±38%, p<0.02 and gastrin (108±25% p<0.01). Insulin release, induced by high glucose concentration was enhanced by both GIP (210 ±38%, p<(0.01) and VIP (48±5%, p<0.001). In addition GIP enhanced the release of glucagon by 179±18% (p<0.001) at 1.4 mmol/l glucose and by 127±24% (p<0.005) at 8.3 mmol/l glucose. Thus no simple inter-relationship appears to exist between the control of the three circulating islet hormones.
Original language | English |
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Pages (from-to) | 413-417 |
Number of pages | 5 |
Journal | Diabetologia |
Volume | 14 |
Issue number | 6 |
DOIs | |
Publication status | Published - Jun 1978 |
Externally published | Yes |
Keywords
- GIP
- Isolated perfused canine pancreas
- VIP
- acetyl choline
- adrenaline
- bombesin
- caerulein
- gastrin
- glucagon
- release of PP
- release of glucagon
- release of insulin
- secretin
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism