PANCREATIC POLYPEPTIDE IN INSULINOMAS, GASTRINOMAS, VIPOMAS, AND GLUCAGONOMAS

J. M. Polak; T. E. Adrian; M. G. Bryant; S. R. Bloom; PH Heitz; A. G.E. Pearse

doi:10.1016/S0140-6736(76)90084-2

PANCREATIC POLYPEPTIDE IN INSULINOMAS, GASTRINOMAS, VIPOMAS, AND GLUCAGONOMAS

J. M. Polak, T. E. Adrian, M. G. Bryant, S. R. Bloom, PH Heitz, A. G.E. Pearse

Research output: Contribution to journal › Article › peer-review

142 Citations (Scopus)

Abstract

In 33 patients studied with endocrine neoplasms of the pancreas more than half the tumours contained pancreatic polypeptide (P.P.) producing cells, and a high radioimmunoassayable concentration of P.P. was found in the tumour extracts. Plasma was available from 28 patients, and very high circulating P.P. concentrations were found in 18. The presence of P.P. in hepatic and lymphnode metastases indicates that its production by the primary neoplasm cannot be ascribed to incidental adherence of normal P.P. cells. Measurements of plasma P.P. levels should be a new aid to diagnosis of pancreatic tumours.

Original language	English
Pages (from-to)	328-330
Number of pages	3
Journal	The Lancet
Volume	307
Issue number	7955
DOIs	https://doi.org/10.1016/S0140-6736(76)90084-2
Publication status	Published - Feb 14 1976
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1016/S0140-6736(76)90084-2

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title = "PANCREATIC POLYPEPTIDE IN INSULINOMAS, GASTRINOMAS, VIPOMAS, AND GLUCAGONOMAS",

abstract = "In 33 patients studied with endocrine neoplasms of the pancreas more than half the tumours contained pancreatic polypeptide (P.P.) producing cells, and a high radioimmunoassayable concentration of P.P. was found in the tumour extracts. Plasma was available from 28 patients, and very high circulating P.P. concentrations were found in 18. The presence of P.P. in hepatic and lymphnode metastases indicates that its production by the primary neoplasm cannot be ascribed to incidental adherence of normal P.P. cells. Measurements of plasma P.P. levels should be a new aid to diagnosis of pancreatic tumours.",

author = "Polak, {J. M.} and Adrian, {T. E.} and Bryant, {M. G.} and Bloom, {S. R.} and PH Heitz and Pearse, {A. G.E.}",

note = "Funding Information: This work was supported by grants from the Medical Research Council, Cancer Campaign, and Volkswagenwerk Stiftung (Hannover). Pure pancreatic polypeptide and its antibodies were generously donated by Dr R. E. Chance and Mrs Nancy E. Moon (Lilly Research Laboratories, Eli Lilly and Co., Indiana- polis, Indiana, U.S.A.). P.H. is on leave from the Department of Pathology, University of Basle; supported by grant of the Swiss National Academy of Medical Sciences.",

year = "1976",

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day = "14",

doi = "10.1016/S0140-6736(76)90084-2",

language = "English",

volume = "307",

pages = "328--330",

journal = "The Lancet",

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T1 - PANCREATIC POLYPEPTIDE IN INSULINOMAS, GASTRINOMAS, VIPOMAS, AND GLUCAGONOMAS

AU - Polak, J. M.

AU - Adrian, T. E.

AU - Bryant, M. G.

AU - Bloom, S. R.

AU - Heitz, PH

AU - Pearse, A. G.E.

N1 - Funding Information: This work was supported by grants from the Medical Research Council, Cancer Campaign, and Volkswagenwerk Stiftung (Hannover). Pure pancreatic polypeptide and its antibodies were generously donated by Dr R. E. Chance and Mrs Nancy E. Moon (Lilly Research Laboratories, Eli Lilly and Co., Indiana- polis, Indiana, U.S.A.). P.H. is on leave from the Department of Pathology, University of Basle; supported by grant of the Swiss National Academy of Medical Sciences.

PY - 1976/2/14

Y1 - 1976/2/14

N2 - In 33 patients studied with endocrine neoplasms of the pancreas more than half the tumours contained pancreatic polypeptide (P.P.) producing cells, and a high radioimmunoassayable concentration of P.P. was found in the tumour extracts. Plasma was available from 28 patients, and very high circulating P.P. concentrations were found in 18. The presence of P.P. in hepatic and lymphnode metastases indicates that its production by the primary neoplasm cannot be ascribed to incidental adherence of normal P.P. cells. Measurements of plasma P.P. levels should be a new aid to diagnosis of pancreatic tumours.

AB - In 33 patients studied with endocrine neoplasms of the pancreas more than half the tumours contained pancreatic polypeptide (P.P.) producing cells, and a high radioimmunoassayable concentration of P.P. was found in the tumour extracts. Plasma was available from 28 patients, and very high circulating P.P. concentrations were found in 18. The presence of P.P. in hepatic and lymphnode metastases indicates that its production by the primary neoplasm cannot be ascribed to incidental adherence of normal P.P. cells. Measurements of plasma P.P. levels should be a new aid to diagnosis of pancreatic tumours.

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JO - The Lancet

JF - The Lancet

IS - 7955

ER -

PANCREATIC POLYPEPTIDE IN INSULINOMAS, GASTRINOMAS, VIPOMAS, AND GLUCAGONOMAS

Abstract

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