Pancreatic polypeptide in insulinomas, gastrinomas, vipomas, and glucagonomas

J. M. Polak; T. E. Adrian; M. G. Bryant; S. R. Bloom; Ph Heitz; A. G.E. Pearse

doi:10.1016/S0140-6736(76)90082-9

Pancreatic polypeptide in insulinomas, gastrinomas, vipomas, and glucagonomas

J. M. Polak, T. E. Adrian, M. G. Bryant, S. R. Bloom, Ph Heitz, A. G.E. Pearse

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Abstract

In 33 patients studied with endocrine neoplasms of the pancreas more than half the tumors contained pancreatic polypeptide (P.P.) producing cells, and a high radioimmunoassayable concentration of P.P. was found in the tumor extracts. Plasma was available from 28 patients, and very high circulating P.P. concentrations were found in 18. The presence of P.P. in hepatic and lymphnode metastases indicates that its production by the primary neoplasm cannot be ascribed to incidental adherence of normal P.P. cells. Measurements of plasma P.P. levels should be a new aid to diagnosis of pancreatic tumors.

Original language	English
Pages (from-to)	328-330
Number of pages	3
Journal	Unknown Journal
Volume	307
Issue number	7955
DOIs	https://doi.org/10.1016/S0140-6736(76)90082-9
Publication status	Published - Jan 1 1976
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1016/S0140-6736(76)90082-9

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abstract = "In 33 patients studied with endocrine neoplasms of the pancreas more than half the tumors contained pancreatic polypeptide (P.P.) producing cells, and a high radioimmunoassayable concentration of P.P. was found in the tumor extracts. Plasma was available from 28 patients, and very high circulating P.P. concentrations were found in 18. The presence of P.P. in hepatic and lymphnode metastases indicates that its production by the primary neoplasm cannot be ascribed to incidental adherence of normal P.P. cells. Measurements of plasma P.P. levels should be a new aid to diagnosis of pancreatic tumors.",

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AU - Bloom, S. R.

AU - Heitz, Ph

AU - Pearse, A. G.E.

PY - 1976/1/1

Y1 - 1976/1/1

N2 - In 33 patients studied with endocrine neoplasms of the pancreas more than half the tumors contained pancreatic polypeptide (P.P.) producing cells, and a high radioimmunoassayable concentration of P.P. was found in the tumor extracts. Plasma was available from 28 patients, and very high circulating P.P. concentrations were found in 18. The presence of P.P. in hepatic and lymphnode metastases indicates that its production by the primary neoplasm cannot be ascribed to incidental adherence of normal P.P. cells. Measurements of plasma P.P. levels should be a new aid to diagnosis of pancreatic tumors.

AB - In 33 patients studied with endocrine neoplasms of the pancreas more than half the tumors contained pancreatic polypeptide (P.P.) producing cells, and a high radioimmunoassayable concentration of P.P. was found in the tumor extracts. Plasma was available from 28 patients, and very high circulating P.P. concentrations were found in 18. The presence of P.P. in hepatic and lymphnode metastases indicates that its production by the primary neoplasm cannot be ascribed to incidental adherence of normal P.P. cells. Measurements of plasma P.P. levels should be a new aid to diagnosis of pancreatic tumors.

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ER -

Pancreatic polypeptide in insulinomas, gastrinomas, vipomas, and glucagonomas

Abstract

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