TY - GEN
T1 - Parameter estimation of essential amino acids in Arabidopsis thaliana using hybrid of bees algorithm and harmony search
AU - Aw, Mei Yee
AU - Mohamad, Mohd Saberi
AU - Chong, Chuii Khim
AU - Deris, Safaai
AU - Remli, Muhammad Akmal
AU - Ismail, Mohd Arfian
AU - Corchado, Juan Manuel
AU - Omatu, Sigeru
N1 - Publisher Copyright:
© Springer Nature Switzerland AG 2019.
PY - 2019
Y1 - 2019
N2 - Mathematical models of metabolic processes are the cornerstone of computational systems biology. In model building, the task of parameter estimation is difficult due to the huge numbers of kinetics parameters involved. The common way of estimating the parameters is to formulate it as an optimization problem. Global optimization methods can be applied by minimizing the distance between experimental data and predicted models. This paper proposes the Hybrid of Bees Algorithm and Harmony Search (BAHS) to estimate the kinetics parameters of essential amino acid production in the aspartate metabolism for Arabidopsis thaliana. The performance of the BAHS is evaluated and compared with other algorithms. The results show that BAHS performed better as it improved the performance of the original BA by 60%. Meanwhile, it takes less computational time to estimate the kinetics parameters of essential amino acid production for Arabidopsis thaliana.
AB - Mathematical models of metabolic processes are the cornerstone of computational systems biology. In model building, the task of parameter estimation is difficult due to the huge numbers of kinetics parameters involved. The common way of estimating the parameters is to formulate it as an optimization problem. Global optimization methods can be applied by minimizing the distance between experimental data and predicted models. This paper proposes the Hybrid of Bees Algorithm and Harmony Search (BAHS) to estimate the kinetics parameters of essential amino acid production in the aspartate metabolism for Arabidopsis thaliana. The performance of the BAHS is evaluated and compared with other algorithms. The results show that BAHS performed better as it improved the performance of the original BA by 60%. Meanwhile, it takes less computational time to estimate the kinetics parameters of essential amino acid production for Arabidopsis thaliana.
KW - Arabidopsis thaliana
KW - Bees algorithm
KW - Computational intelligence
KW - Harmony search
KW - Parameter estimation
KW - Systems biology
UR - http://www.scopus.com/inward/record.url?scp=85052912250&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85052912250&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-98702-6_2
DO - 10.1007/978-3-319-98702-6_2
M3 - Conference contribution
AN - SCOPUS:85052912250
SN - 9783319987019
T3 - Advances in Intelligent Systems and Computing
SP - 9
EP - 16
BT - Practical Applications of Computational Biology and Bioinformatics, 12th International Conference
A2 - Rocha, Miguel
A2 - Mohamad, Mohd Saberi
A2 - De Paz, Juan F.
A2 - Fdez-Riverola, Florentino
A2 - Gonzalez, Pascual
PB - Springer Verlag
T2 - 12th International Conference on Practical Applications of Computational Biology and Bioinformatics, PACBB 2018
Y2 - 20 June 2018 through 22 June 2018
ER -