Parameter estimation of essential amino acids in Arabidopsis thaliana using hybrid of bees algorithm and harmony search

Mei Yee Aw, Mohd Saberi Mohamad, Chuii Khim Chong, Safaai Deris, Muhammad Akmal Remli, Mohd Arfian Ismail, Juan Manuel Corchado, Sigeru Omatu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Mathematical models of metabolic processes are the cornerstone of computational systems biology. In model building, the task of parameter estimation is difficult due to the huge numbers of kinetics parameters involved. The common way of estimating the parameters is to formulate it as an optimization problem. Global optimization methods can be applied by minimizing the distance between experimental data and predicted models. This paper proposes the Hybrid of Bees Algorithm and Harmony Search (BAHS) to estimate the kinetics parameters of essential amino acid production in the aspartate metabolism for Arabidopsis thaliana. The performance of the BAHS is evaluated and compared with other algorithms. The results show that BAHS performed better as it improved the performance of the original BA by 60%. Meanwhile, it takes less computational time to estimate the kinetics parameters of essential amino acid production for Arabidopsis thaliana.

Original languageEnglish
Title of host publicationPractical Applications of Computational Biology and Bioinformatics, 12th International Conference
EditorsMiguel Rocha, Mohd Saberi Mohamad, Juan F. De Paz, Florentino Fdez-Riverola, Pascual Gonzalez
PublisherSpringer Verlag
Pages9-16
Number of pages8
ISBN (Print)9783319987019
DOIs
Publication statusPublished - 2019
Externally publishedYes
Event12th International Conference on Practical Applications of Computational Biology and Bioinformatics, PACBB 2018 - Toledo, Spain
Duration: Jun 20 2018Jun 22 2018

Publication series

NameAdvances in Intelligent Systems and Computing
Volume803
ISSN (Print)2194-5357

Other

Other12th International Conference on Practical Applications of Computational Biology and Bioinformatics, PACBB 2018
Country/TerritorySpain
CityToledo
Period6/20/186/22/18

Keywords

  • Arabidopsis thaliana
  • Bees algorithm
  • Computational intelligence
  • Harmony search
  • Parameter estimation
  • Systems biology

ASJC Scopus subject areas

  • Control and Systems Engineering
  • General Computer Science

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