In this paper, the efficiency of base isolation of an asymmetric single-storey building subjected to the EL-CENTRO earthquake is investigated. Three different isolators (lead rubber bearing, high damping rubber bearing, and coil spring) have been employed and their efficiency in reducing the response to the earthquake tested. A magneto-rheological damper is introduced to improve the efficiency of different isolators. The effect of including the soft soil interaction on the performance of the different isolators was also investigated. The building, on grade slab and backfill are treated as lumped mass parameters in the dynamic modelling. The results indicate that passive base isolation enables the reduction of the response of an asymmetric building under dynamic loads and allows the superstructure to act as rigid body. The high damping rubber bearing performed best among the isolators examined, while semi active control allowed a reduction of ninety percent in the dynamic response. Including soil-structure interaction in the dynamic analysis increased the displacement of the suggested one storey building.