Pepsin Release by Prostaglandin E1 Analogue: A Potential Therapeutic Problem

Marc D. Basson, Karl A. Zucker, Thomas E. Adrian, Michael J. Zdon, Garth H. Ballantyne, Irvin M. Modlin

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Prostaglandins inhibit gastric acid secretion and are independently “cytoprotective” for gastric mucosa. They are currently under clinical investigation for the treatment of peptic ulcers. The effects of the prostaglandin E1 analogue misoprostol on pepsinogen and acid secretion were tested in isolated rabbit gastric glands and enriched parietal cells. Pepsinogen concentrations were measured by iodine 125—labeled albumin digestion and acid secretion indirectly by carbon 14—tagged aminopyrine uptake. Misoprostol inhibited histamine-stimulated acid secretion in parietal cells with 50% inhibition at 10−9 mol/L and maximally (78% inhibition) at 107 mol/L. In contrast, however, misoprostol strongly stimulated pepsinogen secretion by gastric glands with a halfmaximal effect at 10−8 mol/L and maximal stimulation of 227% at 106 mol/L. It is possible that this release of pepsin could compromise the action of prostaglandins in promoting ulcer healing.

Original languageEnglish
Pages (from-to)431-433
Number of pages3
JournalArchives of Surgery
Issue number4
Publication statusPublished - Apr 1988
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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