Peptide YY

T. E. Adrian

Research output: Chapter in Book/Report/Conference proceedingChapter


Peptide YY (PYY) is a hormonal peptide produced by endocrine cells in the intestinal mucosa. This chapter reviews the discovery of the peptide, its structure and that if its gene, its distribution, release mechanism, receptors, biological and physiological effects, its role in pathophysiology and finally its therapeutic potential. In 2002, PYY was shown to have marked inhibitory effects on food intake. Since then there has been an explosion of research into its role in obesity and metabolic disease as well as its potential for therapy in this area.

Original languageEnglish
Title of host publicationThe Curated Reference Collection in Neuroscience and Biobehavioral Psychology
PublisherElsevier Science Ltd.
Number of pages10
ISBN (Electronic)9780128093245
Publication statusPublished - Jan 1 2016


  • Anti-secretory
  • Bariatric surgery
  • Enteroendocrine L-cell
  • Food intake
  • Gastrointestinal hormone
  • Glucose homeostasis
  • Hypothalamus
  • Peptide YY
  • Peptide tyrosine tyrosine
  • Satiety
  • Weight loss
  • Y receptors

ASJC Scopus subject areas

  • Medicine(all)


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