Perinatal outcome of congenital heart disease in a population with high consanguinity

Mohamed A. Hamdan, Fares Chedid, Gharid N. Bekdache, Muzibunissa Begam, Walaa Alsafi, Zainab Sabri, Hisham M. Mirghani

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Objective: To report the perinatal pattern and outcome of fetuses with congenital heart disease (CHD) in consanguineous marriages. Methods: Retrospective chart review was performed for fetuses undergoing fetal echocardiography (FE) in our institution. The primary outcome was survival at 28 days after birth. Results: Between 1 January 2005 and 31 December 2010, 1950 pregnant women carrying 2151 fetuses underwent a total of 2828 FEs. CHD was diagnosed in 152 fetuses (7.1%), and perinatal outcome was available in 120, among which 78 (65%) had consanguineous parents. Thirteen fetuses died in utero, while 86 (71.7%) survived. The most prevalent lesions included left heart obstruction (25.8%), conotruncal malformations (21.7%), septal defects (18.3%), and cardiomyopathy (15.8%). Correct diagnosis was achieved in 92.2% of the cases. Extracardiac malformations occurred in 48.3% of the fetuses and were associated with increased mortality regardless of the type of CHD (P<0.001, odds ratio 6.8, 95% confidence interval 2.7-17.5). Conclusion: Joint FE clinics detect most CHD with high accuracy. Consanguinity contributes to a higher prevalence of fetal cardiac and non-cardiac malformations. The presence of extracardiac anomalies is associated with an increase in perinatal mortality.

Original languageEnglish
Pages (from-to)735-740
Number of pages6
JournalJournal of Perinatal Medicine
Volume43
Issue number6
DOIs
Publication statusPublished - Nov 1 2015

Keywords

  • Cardiac anomalies
  • consanguinity
  • mortality
  • perinatal

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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