TY - JOUR
T1 - Pertussis seronegativity in pregnant women in the city of Al Ain, United Arab Emirates
AU - Narchi, Hassib
AU - Osman, Wafa
AU - George, Junu A.
AU - Almekhaini, Lolowa A.
AU - Souid, Abdul Kader
AU - Alsuwaidi, Ahmed R.
N1 - Funding Information:
We are grateful to Mrs. Fatima Al Shibli, Mrs. Sania Al Hamad, and Dr. Iman Doss for their contribution. The study was funded by a research grant from the United Arab Emirates University (No. 31R074 ). The funding source did not participate in the study design, data collection, analysis and interpretation of the data, or the decision to submit the manuscript for publication.
Publisher Copyright:
© 2019 The Author(s)
PY - 2019/12
Y1 - 2019/12
N2 - Objective: As the current recommendation of administering Tdap (tetanus-diphtheria-acellular pertussis) to all pregnant women has not been widely implemented in the United Arab Emirates (UAE), we aimed to ascertain the prevalence of pertussis seronegativity during pregnancy. Methods: IgG antibodies against Bordetella pertussis toxin (PT) were measured in 213 women attending the antenatal clinic at Oasis hospital, Al Ain, UAE. Results were compared by maternal age, nationality and gestational age with the Kruskal–Wallis test for IgG-PT levels and the Chi-squared test for serology status. Results: The mean age ± SD of the participants was 30.4 ± 5.6 years, mean gestational age ± SD of 25.5 ± 3.3 weeks. Serum concentration of IgG-PT <10 IU/ml were found in 160 out of 213 women (75%; 95% confidence interval 69%, 81%). There was no significant difference in the geometric mean of serum IgG-PT concentration across maternal age (P = 0.80) or nationality (P = 0.90). There were no differences in the prevalence of seronegativity with maternal age (P = 0.65) or nationality (P = 0.90). Conclusion: With a high prevalence of pertussis seronegativity in pregnant women, there is a potential benefit of introducing pertussis vaccination during pregnancy into our national immunization program.
AB - Objective: As the current recommendation of administering Tdap (tetanus-diphtheria-acellular pertussis) to all pregnant women has not been widely implemented in the United Arab Emirates (UAE), we aimed to ascertain the prevalence of pertussis seronegativity during pregnancy. Methods: IgG antibodies against Bordetella pertussis toxin (PT) were measured in 213 women attending the antenatal clinic at Oasis hospital, Al Ain, UAE. Results were compared by maternal age, nationality and gestational age with the Kruskal–Wallis test for IgG-PT levels and the Chi-squared test for serology status. Results: The mean age ± SD of the participants was 30.4 ± 5.6 years, mean gestational age ± SD of 25.5 ± 3.3 weeks. Serum concentration of IgG-PT <10 IU/ml were found in 160 out of 213 women (75%; 95% confidence interval 69%, 81%). There was no significant difference in the geometric mean of serum IgG-PT concentration across maternal age (P = 0.80) or nationality (P = 0.90). There were no differences in the prevalence of seronegativity with maternal age (P = 0.65) or nationality (P = 0.90). Conclusion: With a high prevalence of pertussis seronegativity in pregnant women, there is a potential benefit of introducing pertussis vaccination during pregnancy into our national immunization program.
KW - Maternal immunization
KW - Pertussis
KW - Tdap
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U2 - 10.1016/j.ijid.2019.08.031
DO - 10.1016/j.ijid.2019.08.031
M3 - Article
C2 - 31493522
AN - SCOPUS:85074339547
SN - 1201-9712
VL - 89
SP - 96
EP - 101
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -