Pertuzumab in human epidermal growth-factor receptor 2-positive breast cancer: Clinical and economic considerations

Nathan W.D. Lamond, Tallal Younis

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)


In the absence of specific therapy, the 15%-20% of breast cancers demonstrating human epidermal growth-factor receptor 2 (HER2) protein overexpression and/or gene amplification are characterized by a more aggressive phenotype and poorer prognosis compared to their HER2-negative counterparts. Trastuzumab (Herceptin), the first anti-HER2-targeted therapy, has been associated with improved survival outcomes in HER2-positive breast cancer. However, many patients with early stage disease continue to relapse, and metastatic disease remains incurable. In order to further improve these outcomes, several novel HER2-targeted agents have recently been developed. Pertuzumab (Perjeta), a monoclonal antibody against the HER2 dimerization domain, has also been associated with improved patient outcomes in clinical trials, and has recently been approved in combination with chemotherapy and trastuzumab for neoadjuvant therapy of early stage, HER2-positive breast cancer and first-line treatment of metastatic disease. This review briefly summarizes pertuzumab's clinical development as well as the published evidence supporting its use, and highlights some of the currently unanswered questions that will influence pertuzumab's incorporation into clinical practice.

Original languageEnglish
Pages (from-to)509-521
Number of pages13
JournalInternational Journal of Women's Health
Issue number1
Publication statusPublished - May 16 2014
Externally publishedYes


  • Clinical trials
  • Drug development
  • HER2/neu
  • Novel therapies
  • Targeted anticancer therapy

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology
  • Maternity and Midwifery


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