@article{c53b89e7151c489e82911612e8e486fd,
title = "Pharmacokinetics of K117 and K127, two novel antidote candidates to treat Tabun poisoning",
abstract = "Aims: K117 and K127 are bis-pyridinium aldoximes but K117 is a bis-pyridinium bis-aldoxime while K127 has only one single aldoxime in addition to its amide substituent. Is there any difference in pharmacokinetics in these compounds that otherwise have the same chemical structure? Both K117 and K127 are developed as antidotes in acetylcholinesterase and butyrylcholinesterase poisoning in terrorist attacks or intoxication with other organophosphorous compounds. Their distributions have been scouted in the bodies of rats. Main methods: White male Wistar rats were intramuscularly injected. The animals were sacrificed, tissue samples were homogenized, and either K117 or K127 concentrations were determined using reversed-phase high-performance liquid chromatography. Key findings: Both K117 and K127 were present in all tissues that were analyzed including blood (serum), the brains, cerebrospinal fluid, the eyes, livers, kidneys, lungs and testes. Their pharmacokinetics and body distributions are similar. Significance: Either K117 or K127 meets the essential requirements for antidotes. Dose dependence and kinetics of their distribution were compared to that of other pyridinium aldoximes.",
keywords = "Butyrylcholinesterase, Distribution, HPLC, K117, K127, Pyridinium aldoxime",
author = "K. Tekes and G. Karvaly and S. Nurulain and K. Kuca and K. Musilek and E. Adeghate and Jung, {Y. S.} and H. Kal{\'a}sz",
note = "Funding Information: This project was part of a research cooperation among the Czech Republic, Hungary, the Korean Republic and Poland, and it was financially sponsored by Kal{\'a}sz Teaching and Research Co. (Budapest, Hungary), by the NN126968 grant of the Hungarian National Office for Research, Development and Innovation (Budapest, Hungary) and by the Ministry of Education, Youth and Sports of the Czech Republic (no. 8F17004). Advice and help by Mr. Zolt{\'a}n Szimr{\'o}k, Mr. J{\'a}nos Horv{\'a}th, Mr. Andr{\'a}s Keglevich, Mrs. Gy{\"o}rgyike Guth, Ms. Krisztina Kecsk{\'e}s and Mrs. Bogi Szalacsi are appreciated. Funding Information: This project was part of a research cooperation among the Czech Republic, Hungary, the Korean Republic and Poland, and it was financially sponsored by Kal{\'a}sz Teaching and Research Co. (Budapest, Hungary) , by the NN126968 grant of the Hungarian National Office for Research, Development and Innovation (Budapest, Hungary) and by the Ministry of Education , Youth and Sports of the Czech Republic (no. 8F17004 ). Advice and help by Mr. Zolt{\'a}n Szimr{\'o}k, Mr. J{\'a}nos Horv{\'a}th, Mr. Andr{\'a}s Keglevich, Mrs. Gy{\"o}rgyike Guth, Ms. Krisztina Kecsk{\'e}s and Mrs. Bogi Szalacsi are appreciated. Publisher Copyright: {\textcopyright} 2019",
year = "2019",
month = sep,
day = "1",
doi = "10.1016/j.cbi.2019.108737",
language = "English",
volume = "310",
journal = "Chemico-Biological Interactions",
issn = "0009-2797",
publisher = "Elsevier Ireland Ltd",
}