Pharmacological and antioxidant activities of rhus coriaria l. (sumac)

Halima Alsamri, Khawlah Athamneh, Gianfranco Pintus, Ali H. Eid, Rabah Iratni

Research output: Contribution to journalReview articlepeer-review

75 Citations (Scopus)


Rhus coriaria L. (Anacardiaceae), commonly known as sumac, is a commonly used spice, condiment, and flavoring agent, especially in the Mediterranean region. Owing to its bountiful beneficial values, sumac has been used in traditional medicine for the management and treatment of many ailments including hemorrhoids, wound healing, diarrhea, ulcer, and eye inflammation. This plant is rich in various classes of phytochemicals including flavonoids, tannins, polyphenolic com-pounds, organic acids, and many others. By virtue of its bioactive, Rhus coriaria possesses powerful antioxidant capacities that have ameliorative and therapeutic benefits for many common diseases including cardiovascular disease, diabetes, and cancer. This review describes the phytochemical properties of R. coriaria and then focuses on the potent antioxidant capacities of sumac. We then dissect the cellular and molecular mechanisms of sumac’s action in modulating many pathophysi-ological instigators. We show how accumulating evidence supports the antibacterial, antinocicep-tive, antidiabetic, cardioprotective, neuroprotective, and anticancer effects of this plant, especially that toxicity studies show that sumac is very safe to consume by humans and has little toxicity. Taken together, the findings we summarize here support the utilization of this plant as an attractive target for drug discovery.

Original languageEnglish
Article number73
Pages (from-to)1-28
Number of pages28
Issue number1
Publication statusPublished - Jan 2021


  • Anticancer
  • Antimicrobial
  • Antioxidant
  • Phytochemical
  • Rhus coriaria

ASJC Scopus subject areas

  • Food Science
  • Molecular Biology
  • Physiology
  • Biochemistry
  • Clinical Biochemistry
  • Cell Biology


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