Pharmacological inhibition of poly(ADP-ribose) polymerase inhibits angiogenesis

Mohanraj Rajesh; Partha Mukhopadhyay; Sándor Bátkai; Grzegorz Godlewski; György Haskó; Lucas Liaudet; Pál Pacher

doi:10.1016/j.bbrc.2006.09.049

Pharmacological inhibition of poly(ADP-ribose) polymerase inhibits angiogenesis

Mohanraj Rajesh, Partha Mukhopadhyay, Sándor Bátkai, Grzegorz Godlewski, György Haskó, Lucas Liaudet, Pál Pacher

Research output: Contribution to journal › Article › peer-review

67 Citations (Scopus)

Abstract

Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme which plays an important role in regulating cell death and cellular responses to DNA repair. Pharmacological inhibitors of PARP are being considered as treatment for cancer both in monotherapy as well as in combination with chemotherapeutic agents and radiation, and were also reported to be protective against untoward effects exerted by certain anticancer drugs. Here we show that pharmacological inhibition of PARP with 3-aminobenzamide or PJ-34 dose-dependently reduces VEGF-induced proliferation, migration, and tube formation of human umbilical vein endothelial cells in vitro. These results suggest that treatment with PARP inhibitors may exert additional benefits in various cancers and retinopathies by decreasing angiogenesis.

Original language	English
Pages (from-to)	352-357
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	350
Issue number	2
DOIs	https://doi.org/10.1016/j.bbrc.2006.09.049
Publication status	Published - Nov 17 2006
Externally published	Yes

Keywords

3-AB
Angiogenesis
HUVEC
Migration
PJ-34
Poly(ADP-ribose) polymerase (PARP)
Proliferation
Tube formation

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2006.09.049

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title = "Pharmacological inhibition of poly(ADP-ribose) polymerase inhibits angiogenesis",

abstract = "Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme which plays an important role in regulating cell death and cellular responses to DNA repair. Pharmacological inhibitors of PARP are being considered as treatment for cancer both in monotherapy as well as in combination with chemotherapeutic agents and radiation, and were also reported to be protective against untoward effects exerted by certain anticancer drugs. Here we show that pharmacological inhibition of PARP with 3-aminobenzamide or PJ-34 dose-dependently reduces VEGF-induced proliferation, migration, and tube formation of human umbilical vein endothelial cells in vitro. These results suggest that treatment with PARP inhibitors may exert additional benefits in various cancers and retinopathies by decreasing angiogenesis.",

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author = "Mohanraj Rajesh and Partha Mukhopadhyay and S{\'a}ndor B{\'a}tkai and Grzegorz Godlewski and Gy{\"o}rgy Hask{\'o} and Lucas Liaudet and P{\'a}l Pacher",

note = "Funding Information: This study was supported by the Intramural Research Program of NIH/NIAAA (to P.P.). Dr. Pacher wants to dedicate this work to his beloved mother Iren. ",

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doi = "10.1016/j.bbrc.2006.09.049",

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AU - Rajesh, Mohanraj

AU - Mukhopadhyay, Partha

AU - Bátkai, Sándor

AU - Godlewski, Grzegorz

AU - Haskó, György

AU - Liaudet, Lucas

AU - Pacher, Pál

N1 - Funding Information: This study was supported by the Intramural Research Program of NIH/NIAAA (to P.P.). Dr. Pacher wants to dedicate this work to his beloved mother Iren.

PY - 2006/11/17

Y1 - 2006/11/17

N2 - Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme which plays an important role in regulating cell death and cellular responses to DNA repair. Pharmacological inhibitors of PARP are being considered as treatment for cancer both in monotherapy as well as in combination with chemotherapeutic agents and radiation, and were also reported to be protective against untoward effects exerted by certain anticancer drugs. Here we show that pharmacological inhibition of PARP with 3-aminobenzamide or PJ-34 dose-dependently reduces VEGF-induced proliferation, migration, and tube formation of human umbilical vein endothelial cells in vitro. These results suggest that treatment with PARP inhibitors may exert additional benefits in various cancers and retinopathies by decreasing angiogenesis.

AB - Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme which plays an important role in regulating cell death and cellular responses to DNA repair. Pharmacological inhibitors of PARP are being considered as treatment for cancer both in monotherapy as well as in combination with chemotherapeutic agents and radiation, and were also reported to be protective against untoward effects exerted by certain anticancer drugs. Here we show that pharmacological inhibition of PARP with 3-aminobenzamide or PJ-34 dose-dependently reduces VEGF-induced proliferation, migration, and tube formation of human umbilical vein endothelial cells in vitro. These results suggest that treatment with PARP inhibitors may exert additional benefits in various cancers and retinopathies by decreasing angiogenesis.

KW - 3-AB

KW - Angiogenesis

KW - HUVEC

KW - Migration

KW - PJ-34

KW - Poly(ADP-ribose) polymerase (PARP)

KW - Proliferation

KW - Tube formation

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SN - 0006-291X

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

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ER -

Pharmacological inhibition of poly(ADP-ribose) polymerase inhibits angiogenesis

Abstract

Keywords

ASJC Scopus subject areas

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