TY - JOUR
T1 - Pharmacological Properties of Melanin and its Function in Health
AU - ElObeid, Adila Salih
AU - Kamal-Eldin, Afaf
AU - Abdelhalim, Mohamed Anwar K.
AU - Haseeb, Adil M.
N1 - Funding Information:
The authors would like to extend their sincere appreciation to the Deanship of Scientific Research at King Saud University for its funding of this research through the Research Group Project No. RGP-285.
Publisher Copyright:
© 2016 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society)
PY - 2017/6
Y1 - 2017/6
N2 - The biological pigment melanin is present in most of the biological systems. It manifests a host of biological and pharmacological properties. Its role as a molecule with special properties and functions affecting general health, including photoprotective and immunological action, are well recognized. Its antioxidant, anti-inflammatory, immunomodulatory, radioprotective, hepatic, gastrointestinal and hypoglycaemic benefits have only recently been recognized and studied. It is also associated with certain disorders of the nervous system. In this MiniReview, we consider the steadily increasing literature on the bioavailability and functional activity of melanin. Published literature shows that melanin may play a number of possible pharmacological effects such as protective, stimulatory, diagnostic and curative roles in human health. In this MiniReview, possible health roles and pharmacological effects are considered.
AB - The biological pigment melanin is present in most of the biological systems. It manifests a host of biological and pharmacological properties. Its role as a molecule with special properties and functions affecting general health, including photoprotective and immunological action, are well recognized. Its antioxidant, anti-inflammatory, immunomodulatory, radioprotective, hepatic, gastrointestinal and hypoglycaemic benefits have only recently been recognized and studied. It is also associated with certain disorders of the nervous system. In this MiniReview, we consider the steadily increasing literature on the bioavailability and functional activity of melanin. Published literature shows that melanin may play a number of possible pharmacological effects such as protective, stimulatory, diagnostic and curative roles in human health. In this MiniReview, possible health roles and pharmacological effects are considered.
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U2 - 10.1111/bcpt.12748
DO - 10.1111/bcpt.12748
M3 - Review article
C2 - 28027430
AN - SCOPUS:85014668925
SN - 1742-7835
VL - 120
SP - 515
EP - 522
JO - Pharmacology and Toxicology
JF - Pharmacology and Toxicology
IS - 6
ER -