TY - JOUR
T1 - Phenotype and frequency of Epstein-Barr virus-infected cells in pretreatment blood samples from patients with Hodgkin lymphoma
AU - Khan, Gulfaraz
AU - Lake, Annette
AU - Shield, Lesley
AU - Freeland, June
AU - Andrew, Linda
AU - Alexander, Freda E.
AU - Jackson, Robert
AU - Taylor, Penelope R.A.
AU - McCruden, Elizabeth A.B.
AU - Jarrett, Ruth F.
PY - 2005/5
Y1 - 2005/5
N2 - An accumulating body of data suggests that the Epstein-Barr virus (EBV), a lymphotropic herpesvirus, is involved in the pathogenesis of a proportion of cases of Hodgkin lymphoma (HL). In this study, we showed that the frequency of circulating EBV-infected cells was significantly higher (P < 0.001) in pretreatment blood samples from EBV-associated cases when compared with non-EBV-associated cases. We further showed that in patients with EBV-associated disease, the virus persisted in the peripheral blood in memory B cells. This phenotype is consistent with that seen in healthy seropositive controls, post-transplant patients and patients with acute infectious mononucleosis. The data suggest that an increased frequency of EBV carrying B cells in peripheral blood is associated with EBV-associated HL.
AB - An accumulating body of data suggests that the Epstein-Barr virus (EBV), a lymphotropic herpesvirus, is involved in the pathogenesis of a proportion of cases of Hodgkin lymphoma (HL). In this study, we showed that the frequency of circulating EBV-infected cells was significantly higher (P < 0.001) in pretreatment blood samples from EBV-associated cases when compared with non-EBV-associated cases. We further showed that in patients with EBV-associated disease, the virus persisted in the peripheral blood in memory B cells. This phenotype is consistent with that seen in healthy seropositive controls, post-transplant patients and patients with acute infectious mononucleosis. The data suggest that an increased frequency of EBV carrying B cells in peripheral blood is associated with EBV-associated HL.
KW - Epstein-Barr virus
KW - Hodgkin lymphoma
KW - Memory B-cell
KW - Persistent infection
KW - Polymerase chain reaction
UR - https://www.scopus.com/pages/publications/20044383960
UR - https://www.scopus.com/pages/publications/20044383960#tab=citedBy
U2 - 10.1111/j.1365-2141.2005.05483.x
DO - 10.1111/j.1365-2141.2005.05483.x
M3 - Article
C2 - 15877733
AN - SCOPUS:20044383960
SN - 0007-1048
VL - 129
SP - 511
EP - 519
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 4
ER -