Photoactivatable properties of water-soluble fac-Mn(CO)3 bearing N∧O bidentate pyridine ligands

Rabaa M. Khaled; Danira A. Habashy; Amr Y. Ahmed; Omneya S. Ismael; Sara S. Ibrahim; Mennattallah Abdelfatah; Krzysztof Radacki; Ahmed M. Mansour

doi:10.1016/j.poly.2022.116048

Photoactivatable properties of water-soluble fac-Mn(CO)₃ bearing N^∧O bidentate pyridine ligands

Rabaa M. Khaled, Danira A. Habashy, Amr Y. Ahmed, Omneya S. Ismael, Sara S. Ibrahim, Mennattallah Abdelfatah, Krzysztof Radacki, Ahmed M. Mansour

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Two water-soluble fac-Mn(CO)₃ based complexes of the general formula fac-[MnBr(CO)₃(N^∧O)] (N^∧O = pyridine-2-carboxaldehyde (A), and 2-acetylpyridine (B)) were described for their potential CO releasing properties upon illumination at 468 nm, solvatochromism features and cytotoxicity against different malignant cell lines in both the dark and upon the exposure to light source. Negative solvatochromism may be responsible for the red shift of the metal-to-ligand charge transfer band in increasingly less polar solvents. Compound B, which had been functionalized with 2-acetylpyridine, released CO in water faster than complex A, suggesting the role of the methyl group in regulating the CO release kinetics. According to myoglobin assay, the CO release pathway in water is slower than in DMSO revealing to the role of the solvent in controlling the CO release kinetics of Mn(I) carbon monoxide releasing molecules.

Original language	English
Article number	116048
Journal	Polyhedron
Volume	225
DOIs	https://doi.org/10.1016/j.poly.2022.116048
Publication status	Published - Oct 1 2022
Externally published	Yes

Keywords

Cytotoxicity
Solvatochromism
TDDFT
Tricarbonyl manganese complexes

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

Access to Document

10.1016/j.poly.2022.116048

Cite this

@article{70fe311bc0ee469aa1ad44afcf2b21a4,

title = "Photoactivatable properties of water-soluble fac-Mn(CO)3 bearing N∧O bidentate pyridine ligands",

abstract = "Two water-soluble fac-Mn(CO)3 based complexes of the general formula fac-[MnBr(CO)3(N∧O)] (N∧O = pyridine-2-carboxaldehyde (A), and 2-acetylpyridine (B)) were described for their potential CO releasing properties upon illumination at 468 nm, solvatochromism features and cytotoxicity against different malignant cell lines in both the dark and upon the exposure to light source. Negative solvatochromism may be responsible for the red shift of the metal-to-ligand charge transfer band in increasingly less polar solvents. Compound B, which had been functionalized with 2-acetylpyridine, released CO in water faster than complex A, suggesting the role of the methyl group in regulating the CO release kinetics. According to myoglobin assay, the CO release pathway in water is slower than in DMSO revealing to the role of the solvent in controlling the CO release kinetics of Mn(I) carbon monoxide releasing molecules.",

keywords = "Cytotoxicity, Solvatochromism, TDDFT, Tricarbonyl manganese complexes",

author = "Khaled, {Rabaa M.} and Habashy, {Danira A.} and Ahmed, {Amr Y.} and Ismael, {Omneya S.} and Ibrahim, {Sara S.} and Mennattallah Abdelfatah and Krzysztof Radacki and Mansour, {Ahmed M.}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

month = oct,

day = "1",

doi = "10.1016/j.poly.2022.116048",

language = "English",

volume = "225",

journal = "Polyhedron",

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T1 - Photoactivatable properties of water-soluble fac-Mn(CO)3 bearing N∧O bidentate pyridine ligands

AU - Khaled, Rabaa M.

AU - Habashy, Danira A.

AU - Ahmed, Amr Y.

AU - Ismael, Omneya S.

AU - Ibrahim, Sara S.

AU - Abdelfatah, Mennattallah

AU - Radacki, Krzysztof

AU - Mansour, Ahmed M.

PY - 2022/10/1

Y1 - 2022/10/1

N2 - Two water-soluble fac-Mn(CO)3 based complexes of the general formula fac-[MnBr(CO)3(N∧O)] (N∧O = pyridine-2-carboxaldehyde (A), and 2-acetylpyridine (B)) were described for their potential CO releasing properties upon illumination at 468 nm, solvatochromism features and cytotoxicity against different malignant cell lines in both the dark and upon the exposure to light source. Negative solvatochromism may be responsible for the red shift of the metal-to-ligand charge transfer band in increasingly less polar solvents. Compound B, which had been functionalized with 2-acetylpyridine, released CO in water faster than complex A, suggesting the role of the methyl group in regulating the CO release kinetics. According to myoglobin assay, the CO release pathway in water is slower than in DMSO revealing to the role of the solvent in controlling the CO release kinetics of Mn(I) carbon monoxide releasing molecules.

AB - Two water-soluble fac-Mn(CO)3 based complexes of the general formula fac-[MnBr(CO)3(N∧O)] (N∧O = pyridine-2-carboxaldehyde (A), and 2-acetylpyridine (B)) were described for their potential CO releasing properties upon illumination at 468 nm, solvatochromism features and cytotoxicity against different malignant cell lines in both the dark and upon the exposure to light source. Negative solvatochromism may be responsible for the red shift of the metal-to-ligand charge transfer band in increasingly less polar solvents. Compound B, which had been functionalized with 2-acetylpyridine, released CO in water faster than complex A, suggesting the role of the methyl group in regulating the CO release kinetics. According to myoglobin assay, the CO release pathway in water is slower than in DMSO revealing to the role of the solvent in controlling the CO release kinetics of Mn(I) carbon monoxide releasing molecules.

KW - Cytotoxicity

KW - Solvatochromism

KW - TDDFT

KW - Tricarbonyl manganese complexes

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