Photoinduced Electron Transfer in Encapsulated Heterocycles by Cavitands

Rukayat S. Bojesomo, Na’il Saleh

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Host−guest complexation of small heterocyclic (guest) and macrocyclic cavitands (hosts) organic molecules is still to date a very popular, inexpensive approach that bypasses the burdens of conventional covalent synthesis. Understanding the selection criteria of these chemicals is crucial to the design and potential applications of their supramolecular assemblies. This review surveys examples within the last 15 years (2005–2020) of supramolecular complexes in which the interacting photoinduced electron transfer (PET)-based chromophore and quencher fragments are commonly used in the market with reported CAS numbers. It appears from this survey that the supramolecular effects can be directed to specifically disrupt PET when the nonemissive macrocycles separately encapsulate the fluorescent acceptor or donor molecules, among other specific factors, such as when inducing conformational changes or pKa shift of the donor. On the contrary, synergetic encapsulation of both donor and acceptor molecules, formation of ternary self-assembly at the rim or encapsulation of one component while grafting the other onto the macrocycle, among other specific factors such as the modulation of the excited-state structure of donor, will lead to the enhancement of PET process. In the event the donor or acceptor molecules have multitopic structures, the PET process can repeatedly be switched on and off. It is generally concluded that understanding the criteria for the combination of these available products for the purpose of manipulating their PET efficiency should pave the way for the facile alternative generation of new noncovalently bonded host−guest supramolecular assemblies with a more specific design tailored for more advanced, diverse and economic applications such as chemical sensing, molecular gates, drug delivery and biolabeling.

Original languageEnglish
Pages (from-to)754-762
Number of pages9
JournalPhotochemistry and Photobiology
Volume98
Issue number4
DOIs
Publication statusPublished - Jul 1 2022

ASJC Scopus subject areas

  • Radiation
  • Biochemistry
  • Physical and Theoretical Chemistry

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