Phytochemical properties and anti-proliferative activity of Olea europaea L. leaf extracts against pancreatic cancer cells

Chloe D. Goldsmith, Quan V. Vuong, Elham Sadeqzadeh, Costas E. Stathopoulos, Paul D. Roach, Christopher J. Scarlett

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)


Olea europaea L. leaves are an agricultural waste product with a high concentration of phenolic compounds; especially oleuropein. Oleuropein has been shown to exhibit anti-proliferative activity against a number of cancer types. However, they have not been tested against pancreatic cancer, the fifth leading cause of cancer related death in Western countries. Therefore, water, 50% ethanol and 50% methanol extracts of Corregiola and Frantoio variety Olea europaea L. leaves were investigated for their total phenolic compounds, total flavonoids and oleuropein content, antioxidant capacity and anti-proliferative activity against MiaPaCa-2 pancreatic cancer cells. The extracts only had slight differences in their phytochemical properties, and at 100 and 200 μg/mL, all decreased the viability of the pancreatic cancer cells relative to controls. At 50 μg/mL, the water extract from the Corregiola leaves exhibited the highest anti-proliferative activity with the effect possibly due to early eluting HPLC peaks. For this reason, olive leaf extracts warrant further investigation into their potential anti-pancreatic cancer benefits.

Original languageEnglish
Pages (from-to)12992-13004
Number of pages13
Issue number7
Publication statusPublished - Jul 1 2015
Externally publishedYes


  • Antioxidant activity
  • Biophenols
  • Olea europaea L.
  • Oleuropein
  • Olive leaf
  • Pancreatic cancer
  • Phenolic compounds
  • Phytochemicals

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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