TY - JOUR
T1 - Pituitary adenylate cyclase-activating polypeptide and its receptors in amphibians
AU - Yon, Laurent
AU - Alexandre, David
AU - Montéro, Maité
AU - Chartrel, Nicolas
AU - Jeandel, Lydie
AU - Vallarino, Mauro
AU - Conlon, J. Michael
AU - Kikuyama, Sakae
AU - Fournier, Alain
AU - Gracia-Navarro, Francisco
AU - Roubos, Eric
AU - Chow, Billy
AU - Arimura, Akira
AU - Anouar, Youssef
AU - Vaudry, Hubert
PY - 2001/8/1
Y1 - 2001/8/1
N2 - Pituitary adenylate cyclase-activating polypeptide (PACAP), a novel peptide of the secretin/glucagon/vasoactive intestinal polypeptide superfamily, has been initially characterized in mammals in 1989 and, only 2 years later, its counterpart has been isolated in amphibians. A number of studies conducted in the frog Rana ridibunda have demonstrated that PACAP is widely distributed in the central nervous system (particularly in the hypothalamus and the median eminence) and in peripheral organs including the adrenal gland. The cDNAs encoding the PACAP precursor and 3 types of PACAP receptors have been cloned in amphibians and their distribution has been determined by in situ hybridization histochemistry. Ontogenetic studies have revealed that PACAP is expresssed early in the brain of tadpoles, soon after hatching. In the frog Rana ridibunda, PACAP exerts a large array of biological effects in the brain, pituitary, adrenal gland, and ovary, suggesting that, in amphibians as in mammals, PACAP may act as neurotrophic factor, a neurotransmitter and a neurohormone.
AB - Pituitary adenylate cyclase-activating polypeptide (PACAP), a novel peptide of the secretin/glucagon/vasoactive intestinal polypeptide superfamily, has been initially characterized in mammals in 1989 and, only 2 years later, its counterpart has been isolated in amphibians. A number of studies conducted in the frog Rana ridibunda have demonstrated that PACAP is widely distributed in the central nervous system (particularly in the hypothalamus and the median eminence) and in peripheral organs including the adrenal gland. The cDNAs encoding the PACAP precursor and 3 types of PACAP receptors have been cloned in amphibians and their distribution has been determined by in situ hybridization histochemistry. Ontogenetic studies have revealed that PACAP is expresssed early in the brain of tadpoles, soon after hatching. In the frog Rana ridibunda, PACAP exerts a large array of biological effects in the brain, pituitary, adrenal gland, and ovary, suggesting that, in amphibians as in mammals, PACAP may act as neurotrophic factor, a neurotransmitter and a neurohormone.
KW - Adrenal gland
KW - Central nervous system
KW - Frog
KW - PACAP
KW - PACAP/VIP receptors
KW - VIP
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U2 - 10.1002/jemt.1129
DO - 10.1002/jemt.1129
M3 - Article
C2 - 11458398
AN - SCOPUS:0035426131
SN - 1059-910X
VL - 54
SP - 137
EP - 157
JO - Microscopy Research and Technique
JF - Microscopy Research and Technique
IS - 3
ER -