Plasma peptide YY (PYY) in dumping syndrome

T. E. Adrian, R. G. Long, H. S. Fuessl, S. R. Bloom

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)


The newly isolated hormonal peptide PYY is mainly localized to endocrine cells of the lower intestinal mucosa. The release of PYY by oral glucose was studied in six patients with the dumping syndrome to ascertain the effect of this condition on PYY release. Plasma PYY concentrations were greatly increased following oral glucose in patients with the dumping syndrome compared with healthy controls. In a separate series of experiments, the effect of somatostatin infusion on the PYY release by glucose in these patients was investigated. The release of PYY was completely blocked by infusion of somatostatin, and its release from the bowel in normal subjects may therefore be modulated by local somatostatin in the gut. PYY has been shown to inhibit gastric acid secretion and emptying, at plasma concentrations similar to those seen after glucose, in patients with the dumping syndrome. PYY may therefore be a factor involved in the pathophysiological changes associated with this condition.

Original languageEnglish
Pages (from-to)1145-1148
Number of pages4
JournalDigestive Diseases and Sciences
Issue number12
Publication statusPublished - Dec 1985
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology


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