Polyphenol-Rich Date Palm Fruit Seed (Phoenix Dactylifera L.) Extract Inhibits Labile Iron, Enzyme, and Cancer Cell Activities, and DNA and Protein Damage

Hosam M. Habib, Esmail M. El-Fakharany, Usama D. Souka, Fatma M. Elsebaee, Mohamed G. El-Ziney, Wissam H. Ibrahim

Research output: Contribution to journalArticlepeer-review

Abstract

Date palm fruit seed (Phoenix dactylifera L.) extract (DSE), an under-utilized resource, is a rich source of polyphenols with high potency for disease prevention and antioxidative activities. For the first time, the present study demonstrated that DSE inhibits labile iron activity and DNA and BSA damage and inhibits acetylcholinesterase and tyrosinase activities. Moreover, DSE reduces the proliferation of hepatic, colorectal, and breast cancer cells dose-dependently through apoptotic mechanisms. Furthermore, DSE significantly suppressed the expression of both BCl-2 and P21 genes and increased the P53 expression level when compared with the untreated cells and the 5-FU treated cells. These findings suggest a strong potential for DSE in protecting against the iron-catalyzed ferroptosis that results in programmed cell death. The results also confirm the efficacy of DSE against cancer cells. Therefore, DSE constitutes a valuable candidate for developing functional foods and for natural compound-based chemotherapy for the pharmaceutical and nutraceutical industries.

Original languageEnglish
Article number3536
JournalNutrients
Volume14
Issue number17
DOIs
Publication statusPublished - Sep 2022

Keywords

  • DNA and BSA damage
  • anticancer
  • date seed extract
  • enzyme inhibition
  • labile iron inhibition

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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