TY - JOUR
T1 - Polyphenols
T2 - Chemistry, bioavailability, bioactivity, nutritional aspects and human health benefits: A review
AU - El-Saadony, Mohamed T.
AU - Yang, Tao
AU - Saad, Ahmed M.
AU - Alkafaas, Samar Sami
AU - Elkafas, Sara Samy
AU - Eldeeb, Gehad S.
AU - Mohammed, Dina Mostafa
AU - Salem, Heba M.
AU - Korma, Sameh A.
AU - Loutfy, Samah A.
AU - Alshahran, Mohammad Y.
AU - Ahmed, Ahmed Ezzat
AU - Mosa, Walid F.A.
AU - Abd El-Mageed, Taia A.
AU - Ahmed, Atef F.
AU - Fahmy, Mohamed A.
AU - El-Tarabily, Marawan K.
AU - Mahmoud, Reda M.
AU - AbuQamar, Synan F.
AU - El-Tarabily, Khaled A.
AU - Lorenzo, José M.
N1 - Publisher Copyright:
© 2024 Elsevier B.V.
PY - 2024/10
Y1 - 2024/10
N2 - Polyphenols, including phenolics, alkaloids, and terpenes, are secondary metabolites that are commonly found in fruits, vegetables, and beverages, such as tea, coffee, wine, chocolate, and beer. These compounds have gained considerable attention and market demand because of their potential health benefits. However, their application is limited due to their low absorption rates and reduced tissue distribution efficiency. Engineering polyphenol–protein complexes or conjugates can enhance the antioxidant properties, bioavailability, and stability of polyphenols and improve digestive enzyme hydrolysis, target-specific delivery, and overall biological functions. Complex polyphenols, such as melanin, tannins, and ellagitannins, can promote gut microbiota balance, bolster antioxidant defense, and improve overall human health. Despite these benefits, the safety of polyphenol complexes must be thoroughly evaluated before their use as functional food additives or supplements. This review provides a detailed overview of the types of macromolecular polyphenols, their chemical composition, and their role in food enrichment. The mechanisms by which complex polyphenols act as antioxidative, anti-inflammatory, and anticancer agents have also been discussed.
AB - Polyphenols, including phenolics, alkaloids, and terpenes, are secondary metabolites that are commonly found in fruits, vegetables, and beverages, such as tea, coffee, wine, chocolate, and beer. These compounds have gained considerable attention and market demand because of their potential health benefits. However, their application is limited due to their low absorption rates and reduced tissue distribution efficiency. Engineering polyphenol–protein complexes or conjugates can enhance the antioxidant properties, bioavailability, and stability of polyphenols and improve digestive enzyme hydrolysis, target-specific delivery, and overall biological functions. Complex polyphenols, such as melanin, tannins, and ellagitannins, can promote gut microbiota balance, bolster antioxidant defense, and improve overall human health. Despite these benefits, the safety of polyphenol complexes must be thoroughly evaluated before their use as functional food additives or supplements. This review provides a detailed overview of the types of macromolecular polyphenols, their chemical composition, and their role in food enrichment. The mechanisms by which complex polyphenols act as antioxidative, anti-inflammatory, and anticancer agents have also been discussed.
KW - Bioavailability
KW - Biological activity
KW - Macromolecular polyphenols
KW - Mechanisms of action
KW - Polyphenol-protein complex
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U2 - 10.1016/j.ijbiomac.2024.134223
DO - 10.1016/j.ijbiomac.2024.134223
M3 - Review article
C2 - 39084416
AN - SCOPUS:85200881308
SN - 0141-8130
VL - 277
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
M1 - 134223
ER -