Possible mechanisms underlying calcium signal changes in murine sensory neurons at experimental diabetes

E. Kostyuk; N. Svichar; V. Shishkin; A. Shmigol

doi:10.1007/BF02461237

Possible mechanisms underlying calcium signal changes in murine sensory neurons at experimental diabetes

E. Kostyuk, N. Svichar, V. Shishkin, A. Shmigol

Research output: Contribution to journal › Article › peer-review

Abstract

Numerous investigations indicate that diabetes mellitus is associated with pronounced changes in calcium homeostasis, which in turn lead to substantial complications in most systemic functions. However, similar combined investigations of possible alterations in calcium signalling in the nerve cells are lacking, although pathological changes in nervous functions, including paresthesia and increased pain sensitivity, are common complications of diabetes mellitus in humans. Therefore, we studied the changes in calcium homeostasis in sensory neurons of mice with streptozotocin (STZ)-induced and genetically determined diabetes mellitus.

Original language	English
Pages (from-to)	254-256
Number of pages	3
Journal	Neurophysiology
Volume	29
Issue number	4-5
DOIs	https://doi.org/10.1007/BF02461237
Publication status	Published - 1997
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience
Physiology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF02461237

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abstract = "Numerous investigations indicate that diabetes mellitus is associated with pronounced changes in calcium homeostasis, which in turn lead to substantial complications in most systemic functions. However, similar combined investigations of possible alterations in calcium signalling in the nerve cells are lacking, although pathological changes in nervous functions, including paresthesia and increased pain sensitivity, are common complications of diabetes mellitus in humans. Therefore, we studied the changes in calcium homeostasis in sensory neurons of mice with streptozotocin (STZ)-induced and genetically determined diabetes mellitus.",

author = "E. Kostyuk and N. Svichar and V. Shishkin and A. Shmigol",

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AU - Svichar, N.

AU - Shishkin, V.

AU - Shmigol, A.

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AB - Numerous investigations indicate that diabetes mellitus is associated with pronounced changes in calcium homeostasis, which in turn lead to substantial complications in most systemic functions. However, similar combined investigations of possible alterations in calcium signalling in the nerve cells are lacking, although pathological changes in nervous functions, including paresthesia and increased pain sensitivity, are common complications of diabetes mellitus in humans. Therefore, we studied the changes in calcium homeostasis in sensory neurons of mice with streptozotocin (STZ)-induced and genetically determined diabetes mellitus.

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Possible mechanisms underlying calcium signal changes in murine sensory neurons at experimental diabetes

Abstract

ASJC Scopus subject areas

UN SDGs

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