Prediction of vanillin production in yeast using a hybrid of continuous bees algorithm and flux balance analysis (CBAFBA)

Leang Huat Yin, Yee Wen Choon, Lian En Chai, Chuii Khim Chong, Safaai Deris, Rosli M. Illias, Mohd Saberi Mohamad

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)


Most food and beverage is containing artificial flavor compound. Creation of artificial flavors is not an easy step and it is hardly ever completely effective. In this paper, we introduce an in silico method in optimization of microbial strains of flavor compound synthesis. Previously, there are several algorithms such as Genetic Algorithm, Evolutionary Algorithm, OptKnock tool and other related techniques are widely used to predict the yield of target compound by suggesting the gene knockouts. The used of these algorithms or tools is able to predict the yield of production instead of using try and error method for gene deletions. Nowadays, without using in silico method, the direct experiment methods are not cost effective and time consumed. As we know, the cost of chemical is expensive and not all flavorist able to afford the cost. However, the main limitations of previous algorithms are it failed to optimize the prediction of the yield and suggesting unrealistic flux distribution. Therefore, this paper proposed a hybrid of continuous Bees algorithm and Flux Balance Analysis. The target compound in this research is vanillin. The aim of study is to identify optimum gene knockouts. The results in this paper are the prediction of the yield and the growth rate values of the model. The predictive results showed that the improvement in term of yield which may help in food flavorings.

Original languageEnglish
Title of host publicationAdvances in Biomedical Infrastructure 2013
Subtitle of host publicationProceedings of International Symposium on Biomedical Data Infrastructure (BDI 2013)
PublisherSpringer Verlag
Number of pages16
ISBN (Print)9783642371363
Publication statusPublished - 2013
Externally publishedYes

Publication series

NameStudies in Computational Intelligence
ISSN (Print)1860-949X


  • Bees algorithm
  • Flux balance analysis
  • Optimization
  • Yeast

ASJC Scopus subject areas

  • Artificial Intelligence


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