TY - JOUR
T1 - Predictors of community functioning in schizophrenia and substance use disorder patients
AU - Zhornitsky, Simon
AU - Aubin, Ginette
AU - Desfossés, Joelle
AU - Rizkallah, Élie
AU - Pampoulova, Tania
AU - Lipp, Olivier
AU - Chiasson, Jean Pierre
AU - Stip, Emmanuel
AU - Potvin, Stéphane
N1 - Funding Information:
Acknowledgments This study was funded by an academic partnership between AstraZeneca Pharmaceuticals and the Louis-H Lafontaine Hospital Foundation, and by a Catalyst grant from the Canadian Institute of Health Research. SP is holder of a Junior 1 Young Investigator Award from the Fonds de Recherche en Santé du Québec. ES is holder of the Eli Lilly Chair of schizophrenia from the University of Montreal.
PY - 2013/6
Y1 - 2013/6
N2 - Community functioning is a broad term that encompasses various 'real world' measures of disability among schizophrenia patients. It includes outcomes such as independent living, social competence and behavioural problems - all of which are priorities for treatment among schizophrenia patients, mental health care providers, and family members. An important goal for rehabilitation programs is to identify predictors of community functioning which, in turn, could be used as targets for intervention. The present case-control study examined socio-demographic and substance use disorder (SUD) variables as well as psychiatric, extrapyramidal, and cognitive symptoms as predictors of community functioning in schizophrenia patients with (DD patients; n = 31) and without comorbid SUDs (SCZ patients; n = 31), and non-psychosis substance abusers (SUD patients; n = 39). Psychiatric and extrapyramidal symptoms were evaluated with the Positive and Negative Syndrome Scale, the Calgary Depression Scale for Schizophrenia and the Extrapyramidal Symptoms Rating Scale. Cognition was evaluated using the Cambridge Neuropsychological Test Automated Battery (speed of processing, explicit and working memory). In SCZ patients, community functioning was predicted by explicit memory performance. In DD patients, community functioning was predicted by substance abuse, depression and speed of processing. In SUD patients, community functioning was predicted by substance abuse, positive symptoms and education. Our results suggest that cognition should be among the top treatment priorities in SCZ patients, whereas the key treatment targets in DD patients should be substance abuse and depression. Future studies will need to replicate the current findings, using prospective research designs.
AB - Community functioning is a broad term that encompasses various 'real world' measures of disability among schizophrenia patients. It includes outcomes such as independent living, social competence and behavioural problems - all of which are priorities for treatment among schizophrenia patients, mental health care providers, and family members. An important goal for rehabilitation programs is to identify predictors of community functioning which, in turn, could be used as targets for intervention. The present case-control study examined socio-demographic and substance use disorder (SUD) variables as well as psychiatric, extrapyramidal, and cognitive symptoms as predictors of community functioning in schizophrenia patients with (DD patients; n = 31) and without comorbid SUDs (SCZ patients; n = 31), and non-psychosis substance abusers (SUD patients; n = 39). Psychiatric and extrapyramidal symptoms were evaluated with the Positive and Negative Syndrome Scale, the Calgary Depression Scale for Schizophrenia and the Extrapyramidal Symptoms Rating Scale. Cognition was evaluated using the Cambridge Neuropsychological Test Automated Battery (speed of processing, explicit and working memory). In SCZ patients, community functioning was predicted by explicit memory performance. In DD patients, community functioning was predicted by substance abuse, depression and speed of processing. In SUD patients, community functioning was predicted by substance abuse, positive symptoms and education. Our results suggest that cognition should be among the top treatment priorities in SCZ patients, whereas the key treatment targets in DD patients should be substance abuse and depression. Future studies will need to replicate the current findings, using prospective research designs.
KW - Community functioning
KW - Depression
KW - Memory
KW - Schizophrenia
KW - Substance use disorder
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U2 - 10.1007/s10597-012-9525-y
DO - 10.1007/s10597-012-9525-y
M3 - Article
C2 - 22847727
AN - SCOPUS:84880920279
SN - 0010-3853
VL - 49
SP - 317
EP - 322
JO - Community Mental Health Journal
JF - Community Mental Health Journal
IS - 3
ER -