Preliminary examination of the toxicity of spalting fungal pigments: A comparison between extraction methods

Badria H. Almurshidi, R. C. Van Court, Sarath M.Vega Gutierrez, Stacey Harper, Bryan Harper, Seri C. Robinson

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Spalting fungal pigments have shown potential in technologies ranging from green energy generation to natural colorants. However, their unknown toxicity has been a barrier to industrial adoption. In order to gain an understanding of the safety of the pigments, zebrafish embryos were exposed to multiple forms of liquid media and solvent-extracted pigments with concentrations of purified pigment ranging from 0 to 50 mM from Chlorociboria aeruginosa, Chlorociboria aeruginascens, and Scytalidium cuboideum. Purified xylindein from Chlorociboria sp. did not show toxicity at any tested concentration, while the red pigment dramada from S. cuboideum was only associated with significant toxicity above 23.2 uM. However, liquid cultures and pigment extracted into dichloro-methane (DCM) showed toxicity, suggesting the co-production of bioactive secondary metabolites. Future research on purification and the bioavailability of the red dramada pigment will be important to identify appropriate use; however, purified forms of the blue-green pigment xylindein are likely safe for use across industries. This opens the door to the adoption of green technologies based on these pigments, with potential to replace synthetic colorants and less stable natural pig-ments.

Original languageEnglish
Article number155
Pages (from-to)1-16
Number of pages16
JournalJournal of Fungi
Volume7
Issue number2
DOIs
Publication statusPublished - Feb 2021
Externally publishedYes

Keywords

  • Chlorociboria ae-ruginascens Scytalidium cuboideum
  • Chlorociboria aeruginosa
  • Dramada
  • Fungal pigment
  • Natural colorant
  • Natural pigment
  • Spalting
  • Xylindein

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Plant Science
  • Microbiology (medical)

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