Preliminary results of a single-arm pilot study to assess the safety and efficacy of visnadine, prenylflavonoids and bovine colostrum in postmenopausal sexually active women affected by vulvovaginal atrophy

Antonio Simone Laganà; Salvatore Giovanni Vitale; Lily Stojanovska; Irene Lambrinoudaki; Vasso Apostolopoulos; Benito Chiofalo; Laura Rizzo; Francesca Basile

doi:10.1016/j.maturitas.2017.12.015

Preliminary results of a single-arm pilot study to assess the safety and efficacy of visnadine, prenylflavonoids and bovine colostrum in postmenopausal sexually active women affected by vulvovaginal atrophy

Antonio Simone Laganà
, Salvatore Giovanni Vitale
, Lily Stojanovska
, Irene Lambrinoudaki
, Vasso Apostolopoulos
, Benito Chiofalo
, Laura Rizzo
, Francesca Basile

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

This single-arm pilot study enrolled 47 post-menopausal women affected by vulvovaginal atrophy (VVA). The Vaginal Health Index Score (VHIS) was evaluated for all women and all completed the Female Sexual Function Index (FSFI) questionnaire at baseline (T0) and after 15 days of vaginal cream treatment with one application per day (T1). Following treatment there was a significant improvement in all VHIS parameters and total score (p < 0.0001). Similarly, there was a significant improvement on four FSFI domains (lubrication, orgasm, satisfaction and pain) and total score (p = 0.001). None of the patients reported any local or systemic side-effects during treatment.

Original language	English
Pages (from-to)	78-80
Number of pages	3
Journal	Maturitas
Volume	109
DOIs	https://doi.org/10.1016/j.maturitas.2017.12.015
Publication status	Published - Mar 2018
Externally published	Yes

Keywords

Bovine colostrum
Menopause
Prenylflavonoids
Sexual wellbeing
Visnadine
Vulvovaginal atrophy

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology
Obstetrics and Gynaecology

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Laganà, A. S., Vitale, S. G., Stojanovska, L., Lambrinoudaki, I., Apostolopoulos, V., Chiofalo, B., Rizzo, L., & Basile, F. (2018). Preliminary results of a single-arm pilot study to assess the safety and efficacy of visnadine, prenylflavonoids and bovine colostrum in postmenopausal sexually active women affected by vulvovaginal atrophy. Maturitas, 109, 78-80. https://doi.org/10.1016/j.maturitas.2017.12.015

Preliminary results of a single-arm pilot study to assess the safety and efficacy of visnadine, prenylflavonoids and bovine colostrum in postmenopausal sexually active women affected by vulvovaginal atrophy. / Laganà, Antonio Simone; Vitale, Salvatore Giovanni; Stojanovska, Lily et al.
In: Maturitas, Vol. 109, 03.2018, p. 78-80.

Research output: Contribution to journal › Article › peer-review

Laganà, AS, Vitale, SG, Stojanovska, L, Lambrinoudaki, I, Apostolopoulos, V, Chiofalo, B, Rizzo, L & Basile, F 2018, 'Preliminary results of a single-arm pilot study to assess the safety and efficacy of visnadine, prenylflavonoids and bovine colostrum in postmenopausal sexually active women affected by vulvovaginal atrophy', Maturitas, vol. 109, pp. 78-80. https://doi.org/10.1016/j.maturitas.2017.12.015

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title = "Preliminary results of a single-arm pilot study to assess the safety and efficacy of visnadine, prenylflavonoids and bovine colostrum in postmenopausal sexually active women affected by vulvovaginal atrophy",

abstract = "This single-arm pilot study enrolled 47 post-menopausal women affected by vulvovaginal atrophy (VVA). The Vaginal Health Index Score (VHIS) was evaluated for all women and all completed the Female Sexual Function Index (FSFI) questionnaire at baseline (T0) and after 15 days of vaginal cream treatment with one application per day (T1). Following treatment there was a significant improvement in all VHIS parameters and total score (p < 0.0001). Similarly, there was a significant improvement on four FSFI domains (lubrication, orgasm, satisfaction and pain) and total score (p = 0.001). None of the patients reported any local or systemic side-effects during treatment.",

keywords = "Bovine colostrum, Menopause, Prenylflavonoids, Sexual wellbeing, Visnadine, Vulvovaginal atrophy",

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AU - Laganà, Antonio Simone

AU - Vitale, Salvatore Giovanni

AU - Stojanovska, Lily

AU - Lambrinoudaki, Irene

AU - Apostolopoulos, Vasso

AU - Chiofalo, Benito

AU - Rizzo, Laura

AU - Basile, Francesca

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AB - This single-arm pilot study enrolled 47 post-menopausal women affected by vulvovaginal atrophy (VVA). The Vaginal Health Index Score (VHIS) was evaluated for all women and all completed the Female Sexual Function Index (FSFI) questionnaire at baseline (T0) and after 15 days of vaginal cream treatment with one application per day (T1). Following treatment there was a significant improvement in all VHIS parameters and total score (p < 0.0001). Similarly, there was a significant improvement on four FSFI domains (lubrication, orgasm, satisfaction and pain) and total score (p = 0.001). None of the patients reported any local or systemic side-effects during treatment.

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KW - Menopause

KW - Prenylflavonoids

KW - Sexual wellbeing

KW - Visnadine

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Preliminary results of a single-arm pilot study to assess the safety and efficacy of visnadine, prenylflavonoids and bovine colostrum in postmenopausal sexually active women affected by vulvovaginal atrophy

Abstract

Keywords

ASJC Scopus subject areas

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