Abstract
Alkylresorcinols (AR) in plasma samples have been suggested to be short- to medium-term biomarkers of whole grain wheat and rye intake. In the present study, we investigated whether AR are present in human adipose tissues, and if content correlated with long-term whole grain bread intake. Furthermore, we investigated if the relative AR homologue composition reflected what has been found previously in the habitual diet of Swedes. Biopsy samples (10-25mg) from free-living Swedish women (n 20) were analysed by GC-MS. The mean total AR concentration in the samples was 054 (sd 035)g/g, ranging from below limit of quantification (<008g/g) to 150g/g. Whole grain bread intake was significantly correlated with plasma total AR content (r 048, P<005), and the C17:0/C21:0 ratio was 035 (sd 024), which is similar to what is found in plasma among free-living subjects consuming a mixed whole grain wheat and rye diet. These results suggest that AR in the adipose tissue should be evaluated as a long-term biomarker of whole grain wheat and rye intake.
Original language | English |
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Pages (from-to) | 633-636 |
Number of pages | 4 |
Journal | British Journal of Nutrition |
Volume | 104 |
Issue number | 5 |
DOIs | |
Publication status | Published - Sept 14 2010 |
Externally published | Yes |
Keywords
- Adipose tissue
- Alkylresorcinols
- Biomarker
- Long term
- Whole grain
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics