TY - JOUR
T1 - Prevalence, determinants, and reasons for malaria vaccine hesitancy among caregivers of under-five children in Nigeria
T2 - Results from a nationwide cross-sectional survey
AU - Kabir Sulaiman, Sahabi
AU - Isma'il Tsiga-Ahmed, Fatimah
AU - Sale Musa, Muhammad
AU - Kabir Sulaiman, Abdulwahab
AU - Muhammad Dayyab, Farouq
AU - AB Khan, Moien
AU - Idris Ahmad, Saidu
AU - Abasi-okot Akpan, Udoyen
AU - Ibrahim Usman, Ummu Kulthum
AU - Tjjani Bako, Abdulaziz
N1 - Funding Information:
The authors of this manuscript wish to acknowledge the tremendous contribution made by the malaria vaccine acceptability in Nigeria (M-VAN) survey collaborators whose hard work in sharing the survey link made it possible for the survey to circulate widely across to include different tribes and communities within the country: Aminu Hussein Ungogo,1 Oni Deborah Oluwatimileyin,2 Salisu Abubakar Haruna,3 Olatona Oluwapelumi,4 Peteranaba Sylviastella,5 Jabir Yakubu,6 Ayemieye Tamara-Ifie,7 Musa Muhammad Sani,8 Moses Azi John,9 Yesir Adeyemi Kareem,10 Suleiman Oyinlomo Balogun,11 Success Analikwu,12 Godwin Oboyi,13 Aminu Yusuf Abubakar,14 Abubakar Yakubu,15 Nomeh Chinonso Emmanuel,16 Jibrin Usman Danlamin,17 Chika Chijioke,18 Hadiza Adamu Dogo,19 Saeed Sulaiman,20 Gambo Ibrahim,21 Nwokejiezi Maurice Ugonna,22 (see supplementary file 4 for a list of the M-VAN survey national collaborators along with their affiliations and assigned states of representation).
Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/2/17
Y1 - 2023/2/17
N2 - Objective: Malaria contributes to an enormous global burden of disease and mortality, especially in children. Approximately one in every four global cases and deaths from malaria occurs in Nigeria. This study aims to evaluate the prevalence and correlates of community hesitancy to the malaria vaccine, including the reasons for the hesitancy, following the approval of the RTS,S malaria vaccine by the World Health Organization (WHO). Methods: This was a nationwide cross-sectional online survey of Nigerian adults conducted from 20th October to 30th November 2021. Participants who replied ‘no' or ‘maybe’ to a question assessing their willingness to accept the RTS,S malaria vaccine were considered “hesitant”. We fit a multivariate logistic regression model to report the adjusted odds ratio (aOR) and 95 % confidence interval (CI) for the factors associated with vaccine hesitancy. Findings: Among 3377 total respondents (1961 [57.86 %] males; mean age [SD]: 30[9.1]), 1010 (29.91 %) were hesitant. Receiving information about the RTS,S malaria vaccine initially from healthcare workers (vs. the internet) (aOR:0.55; 95 % CI:0.35–0.87) was significantly associated with lower odds of hesitancy. Conversely, earning a high income of over NGN100, 000 (vs. < NGN 30,000) per month (aOR: 2.10, 95 % CI: 1.36–3.24), belonging to other religious groups (vs. Islam) (aOR:3.25, 95 % CI:1.18–8.98), and having a family size of more than ten (vs. < 5) (aOR:1.84; 95 % CI:1.08–3.13) were significantly associated with a higher odds of hesitancy. The main reasons for vaccine hesitancy included fear of vaccine adverse effects (34.95 %), availability of other malaria preventive measures (33.96 %) and not seeing the positive effect of the vaccine in others first (32.97 %). Conclusion: The findings of this survey provide a valuable blueprint for the development of targeted interventions to facilitate caregiver acceptance of the RTS,S vaccine.
AB - Objective: Malaria contributes to an enormous global burden of disease and mortality, especially in children. Approximately one in every four global cases and deaths from malaria occurs in Nigeria. This study aims to evaluate the prevalence and correlates of community hesitancy to the malaria vaccine, including the reasons for the hesitancy, following the approval of the RTS,S malaria vaccine by the World Health Organization (WHO). Methods: This was a nationwide cross-sectional online survey of Nigerian adults conducted from 20th October to 30th November 2021. Participants who replied ‘no' or ‘maybe’ to a question assessing their willingness to accept the RTS,S malaria vaccine were considered “hesitant”. We fit a multivariate logistic regression model to report the adjusted odds ratio (aOR) and 95 % confidence interval (CI) for the factors associated with vaccine hesitancy. Findings: Among 3377 total respondents (1961 [57.86 %] males; mean age [SD]: 30[9.1]), 1010 (29.91 %) were hesitant. Receiving information about the RTS,S malaria vaccine initially from healthcare workers (vs. the internet) (aOR:0.55; 95 % CI:0.35–0.87) was significantly associated with lower odds of hesitancy. Conversely, earning a high income of over NGN100, 000 (vs. < NGN 30,000) per month (aOR: 2.10, 95 % CI: 1.36–3.24), belonging to other religious groups (vs. Islam) (aOR:3.25, 95 % CI:1.18–8.98), and having a family size of more than ten (vs. < 5) (aOR:1.84; 95 % CI:1.08–3.13) were significantly associated with a higher odds of hesitancy. The main reasons for vaccine hesitancy included fear of vaccine adverse effects (34.95 %), availability of other malaria preventive measures (33.96 %) and not seeing the positive effect of the vaccine in others first (32.97 %). Conclusion: The findings of this survey provide a valuable blueprint for the development of targeted interventions to facilitate caregiver acceptance of the RTS,S vaccine.
KW - Acceptance/Hesitancy/Refusal
KW - Caregivers of under-five children
KW - Immunization
KW - Malaria
KW - RTS,S malaria vaccine
UR - http://www.scopus.com/inward/record.url?scp=85147291623&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85147291623&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2023.01.060
DO - 10.1016/j.vaccine.2023.01.060
M3 - Article
C2 - 36725434
AN - SCOPUS:85147291623
SN - 0264-410X
VL - 41
SP - 1503
EP - 1512
JO - Vaccine
JF - Vaccine
IS - 8
ER -