TY - JOUR
T1 - Processing of social emotion in patients with schizophrenia and substance use disorder
T2 - An fMRI study
AU - Potvin, Stéphane
AU - Mancini-Marïe, Adham
AU - Fahim, Cherine
AU - Mensour, Boualem
AU - Stip, Emmanuel
N1 - Funding Information:
Correspondence should be addressed to: Emmanuel Stip, Centre de recherche Fernand-Seguin, 7331, rue Hochelaga, Montréal (Québec) H1N 3V2 Canada. E-mail: emmanuel.stip@umontreal.ca This study was supported by grants from the Fonds de la Recherche en Santé du Québec (FRSQ), AstraZeneca Pharmaceuticals, University of Montreal Eli Lilly Chair of Schizophrenia Fund and the Canadian Institute of Health Research (CIHR). The authors would like to thank Lahcen Aït Bentaleb, Pierre Lalonde, Marcel Wolfe and Jean M’Pania for their assistance in patient recruitment. Photos of multimedia clips used are for non-profit making, promotional purposes, and no copyright infringement is intended.
PY - 2007/6
Y1 - 2007/6
N2 - The lifetime prevalence of substance use disorders among schizophrenia patients is close to 50%. The negative consequences of substance abuse in schizophrenia are well documented, but the aetiology of this comorbid condition remains unknown. Mounting evidence suggests that dual-diagnosis patients have fewer negative symptoms and better social skills, compared to non-abusing patients. We hypothesized that schizophrenia patients with substance use disorder (SCZ-SUD) would display increased cerebral activations in response to socioemotional stimuli, relative to patients with no SUD (SCZ). Schizophrenia patients (DSM-IV criteria) were divided into two groups: patients with (n = 12) and without (n = 11) substance use (alcohol and/or cannabis). Using functional magnetic resonance imaging (fMRI), patients were scanned during passive viewing of an emotional film excerpt with social content. Loci of activation were identified in the right mPFC (BA 10) and the right supramarginal gyrus (BA 40) in SCZ-SUD patients, and in the left pons in SCZ patients. Relative to SCZ patients, increased loci of activation were found in the right superior parietal cortex (BA 7) and the left medial prefrontal cortex (BA 10) in SCZ-SUD patients, who reported higher subjective emotional experience on a self-report scale. To our knowledge, this is the first fMRI study to assess social emotions in dual-diagnosis schizophrenia. Our results suggest that socioemotional processing may be less impaired in dual diagnosis, which recruited brain regions seemingly involved in "social cognition." Further studies on the topic are warranted.
AB - The lifetime prevalence of substance use disorders among schizophrenia patients is close to 50%. The negative consequences of substance abuse in schizophrenia are well documented, but the aetiology of this comorbid condition remains unknown. Mounting evidence suggests that dual-diagnosis patients have fewer negative symptoms and better social skills, compared to non-abusing patients. We hypothesized that schizophrenia patients with substance use disorder (SCZ-SUD) would display increased cerebral activations in response to socioemotional stimuli, relative to patients with no SUD (SCZ). Schizophrenia patients (DSM-IV criteria) were divided into two groups: patients with (n = 12) and without (n = 11) substance use (alcohol and/or cannabis). Using functional magnetic resonance imaging (fMRI), patients were scanned during passive viewing of an emotional film excerpt with social content. Loci of activation were identified in the right mPFC (BA 10) and the right supramarginal gyrus (BA 40) in SCZ-SUD patients, and in the left pons in SCZ patients. Relative to SCZ patients, increased loci of activation were found in the right superior parietal cortex (BA 7) and the left medial prefrontal cortex (BA 10) in SCZ-SUD patients, who reported higher subjective emotional experience on a self-report scale. To our knowledge, this is the first fMRI study to assess social emotions in dual-diagnosis schizophrenia. Our results suggest that socioemotional processing may be less impaired in dual diagnosis, which recruited brain regions seemingly involved in "social cognition." Further studies on the topic are warranted.
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U2 - 10.1080/17470910701376787
DO - 10.1080/17470910701376787
M3 - Article
C2 - 18633810
AN - SCOPUS:34249992566
SN - 1747-0919
VL - 2
SP - 106
EP - 116
JO - Social Neuroscience
JF - Social Neuroscience
IS - 2
ER -