Prognostic impact of anemia on the mortality of United Arab Emirates nationals with cardiovascular disease

Saif Al-Shamsi, Ghada S.M. Al-Bluwi, Maitha Al Shamsi, Nouf Al Kaabi, Sara Al Khemeiri, Noura Baniyas

Research output: Contribution to journalArticlepeer-review


Background: Cardiovascular disease is the leading cause of death worldwide. Multiple risk factors, including low hemoglobin levels, have been associated with poor outcomes in patients with cardiovascular disease. However, the long-term impact of anemia on death has not been investigated in high-risk patients in the United Arab Emirates. Therefore, this study evaluated whether anemia is a significant predictor of mortality in United Arab Emirates nationals with cardiovascular disease over 10 years. Methods: A retrospective cohort study was conducted in an adult population of United Arab Emirates nationals with a history of cardiovascular disease, recruited from a tertiary healthcare facility. Electronic medical records between April 2008 and December 2008 were reviewed, and follow-up was conducted until December 2019. The survival functions for all-cause mortality in the presence and absence of anemia were compared using univariate Kaplan–Meier analysis with a log-rank test. The association between anemia and all-cause mortality was evaluated using a multivariable Cox regression model. Results: A total of 224 patients were included in the follow-up for 10.5 years. At baseline, 46% of the patients had anemia, with a mean Hgb level of 105.5 ^ 28.0 g/L. Patients with anemia were older (68 vs. 63 years, p ¼ 0.001) and had a higher rate of chronic kidney disease (37.5% vs. 17.5%, p ¼ 0.001) than those without anemia. A total of 77 (34.4%) deaths were recorded by the end of the follow-up period. Risk of all-cause mortality was significantly higher in patients with anemia than in those without (hazard ratio ¼ 2.03, 95% confidence interval ¼ 1.22–3.40, p ¼ 0.006). Age and chronic kidney disease were also statistically significant predictors of death (p, 0.001 and p ¼ 0.001, respectively). Conclusion: Anemia is an independent predictor of all-cause mortality in United Arab Emirates nationals with underlying cardiovascular disease. Early intervention and treatment for anemia may improve clinical outcomes in this population.

Original languageEnglish
Article number3
JournalQatar Medical Journal
Issue number1
Publication statusPublished - 2022


  • Anemia
  • United Arab Emirates
  • cardiovascular disease
  • mortality

ASJC Scopus subject areas

  • General Medicine


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