Abstract
In this study we have investigated the levels of prolactin, growth hormone, and insulin-like growth factor-1 in plasma and in tissue extracts of ankle joints of rats with acute or chronic adjuvant arthritis using enzyme immunoassay (EIA) and radioimmunoassay (RIA). We found a stable content of prolactin in plasma of the different groups but a significantly increased concentration of growth hormone was observed in the plasma of the group with chronic arthritis. Moreover, an increased concentration of insulin-like growth factor-1 was noted in the plasma of the acute group. This evidently had returned to normal levels in the chronic group. In contrast, decreased concentrations of prolactin, growth hormone, and insulin-like growth factor-1 were found in tissue extracts of ankle joints of the group with chronic arthritis. The changes in the levels of these hormones in adjuvant arthritis might suggest that they play a role in the pathogenesis of the disease. Understanding the mechanism(s) of hormonal participation in adjuvant arthritis may open new treatment strategies for rheumatoid arthritis and other inflammatory disorders.
Original language | English |
---|---|
Pages (from-to) | 368-373 |
Number of pages | 6 |
Journal | Scandinavian Journal of Rheumatology |
Volume | 28 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1999 |
Keywords
- Adjuvant arthritis
- Ankle
- GH
- IGF-1
- Plasma
- Prolactin
ASJC Scopus subject areas
- Immunology and Allergy
- Rheumatology
- Immunology