Prolactin, growth hormone, and IGF-1 in ankles and plasma of adjuvant arthritic rats

Adlan M. Elhassan, Abdu Adem, Isam A. Suliman, Amged Mustafa, J. Urban Lindgren

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

In this study we have investigated the levels of prolactin, growth hormone, and insulin-like growth factor-1 in plasma and in tissue extracts of ankle joints of rats with acute or chronic adjuvant arthritis using enzyme immunoassay (EIA) and radioimmunoassay (RIA). We found a stable content of prolactin in plasma of the different groups but a significantly increased concentration of growth hormone was observed in the plasma of the group with chronic arthritis. Moreover, an increased concentration of insulin-like growth factor-1 was noted in the plasma of the acute group. This evidently had returned to normal levels in the chronic group. In contrast, decreased concentrations of prolactin, growth hormone, and insulin-like growth factor-1 were found in tissue extracts of ankle joints of the group with chronic arthritis. The changes in the levels of these hormones in adjuvant arthritis might suggest that they play a role in the pathogenesis of the disease. Understanding the mechanism(s) of hormonal participation in adjuvant arthritis may open new treatment strategies for rheumatoid arthritis and other inflammatory disorders.

Original languageEnglish
Pages (from-to)368-373
Number of pages6
JournalScandinavian Journal of Rheumatology
Volume28
Issue number6
DOIs
Publication statusPublished - 1999

Keywords

  • Adjuvant arthritis
  • Ankle
  • GH
  • IGF-1
  • Plasma
  • Prolactin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology

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