TY - GEN
T1 - Protein-protein interaction prediction using homology and inter-domain linker region information
AU - Zaki, Nazar
PY - 2009
Y1 - 2009
N2 - One of the central problems in modern biology is to identify the complete set of interactions among proteins in a cell. The structural interaction of proteins and their domains in networks is one of the most basic molecular mechanisms for biological cells. Structural evidence indicates that, interacting pairs of close homologs usually interact in the same way. In this chapter, we make use of both homology and inter-domain linker region knowledge to predict interaction between protein pairs solely by amino acid sequence information. High quality core set of 150 yeast proteins obtained from the Database of Interacting Proteins (DIP) was considered to test the accuracy of the proposed method. The strongest prediction of the method reached over 70% accuracy. These results show great potential for the proposed method.
AB - One of the central problems in modern biology is to identify the complete set of interactions among proteins in a cell. The structural interaction of proteins and their domains in networks is one of the most basic molecular mechanisms for biological cells. Structural evidence indicates that, interacting pairs of close homologs usually interact in the same way. In this chapter, we make use of both homology and inter-domain linker region knowledge to predict interaction between protein pairs solely by amino acid sequence information. High quality core set of 150 yeast proteins obtained from the Database of Interacting Proteins (DIP) was considered to test the accuracy of the proposed method. The strongest prediction of the method reached over 70% accuracy. These results show great potential for the proposed method.
KW - Homology
KW - Inter-domain Linker Region
KW - Prediction
KW - Protein-Protein Interaction
KW - Yeast protein
UR - http://www.scopus.com/inward/record.url?scp=78651521681&partnerID=8YFLogxK
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U2 - 10.1007/978-90-481-2311-7_54
DO - 10.1007/978-90-481-2311-7_54
M3 - Conference contribution
AN - SCOPUS:78651521681
SN - 9789048123100
T3 - Lecture Notes in Electrical Engineering
SP - 635
EP - 645
BT - Advances in Electrical Engineering and Computational Science
ER -