Protein-protein interaction prediction using homology and inter-domain linker region information

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Citations (Scopus)


One of the central problems in modern biology is to identify the complete set of interactions among proteins in a cell. The structural interaction of proteins and their domains in networks is one of the most basic molecular mechanisms for biological cells. Structural evidence indicates that, interacting pairs of close homologs usually interact in the same way. In this chapter, we make use of both homology and inter-domain linker region knowledge to predict interaction between protein pairs solely by amino acid sequence information. High quality core set of 150 yeast proteins obtained from the Database of Interacting Proteins (DIP) was considered to test the accuracy of the proposed method. The strongest prediction of the method reached over 70% accuracy. These results show great potential for the proposed method.

Original languageEnglish
Title of host publicationAdvances in Electrical Engineering and Computational Science
Number of pages11
Publication statusPublished - 2009

Publication series

NameLecture Notes in Electrical Engineering
Volume39 LNEE
ISSN (Print)1876-1100
ISSN (Electronic)1876-1119


  • Homology
  • Inter-domain Linker Region
  • Prediction
  • Protein-Protein Interaction
  • Yeast protein

ASJC Scopus subject areas

  • Industrial and Manufacturing Engineering


Dive into the research topics of 'Protein-protein interaction prediction using homology and inter-domain linker region information'. Together they form a unique fingerprint.

Cite this