Psoriasis: A fresh look

Ibrahim Galadari, Mohamed Omar Sharif, Hassan Galadari

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Psoriasis is a disease characterized by scaly skin lesions secondary to keratinocyte hyperplasia. The presence of active T cells in the lesions, experimental observations on disease transfer, and therapeutic efficacy of specific immunosuppressive drugs have led to the identification of the activated T lymphocyte as the primary factor for keratinocyte stimulation. Understanding the pathways of pathogenesis is fundamental in evolving therapies for intervention at different points in the pathogenic model and for curtailing the process. Advances in biotechnological methods have helped to create designer molecules and proteins that specifically recognize target receptors and chemicals that modify their actions. These drugs, termed "biologic response modifiers," are now being studied as specific immunosuppressive agents producing different T-cell and cytokine effects in psoriasis.

Original languageEnglish
Pages (from-to)491-502
Number of pages12
JournalClinics in Dermatology
Volume23
Issue number5
DOIs
Publication statusPublished - Sep 2005

ASJC Scopus subject areas

  • Dermatology

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