Pyruvate provides cardioprotection in the experimental model of myocardial ischemic reperfusion injury

Dharamvir Singh Arya, Pankaj Bansal, Shreesh Kumar Ojha, Mukesh Nandave, Ipseeta Mohanty, Suresh Kumar Gupta

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

The present study was designed to evaluate the cardioprotective potential of pyruvate and to characterize the mechanism underlying the protection. Wistar albino rats were randomly divided into three groups. Two groups were administered saline orally (sham, ischemia-reperfusion (I-R) control group) and animals of third group received pyruvate (500 mg/kg) for 4 weeks. On the 29th day, animals of the I-R control and pyruvate treated groups underwent 45 min of occlusion of the left anterior descending (LAD) coronary artery and were thereafter reperfused for 60 min. In the I-R control group, a significant cardiac necrosis, depressed mean arterial pressure (MAP) and heart rate (HR), decline in myocardial antioxidant status and elevation in lipid peroxidation were observed as compared to sham control. Pyruvate treatment restored the myocardial antioxidant status and favorably modulated the altered MAP as compared to I-R control. Furthermore, I/R-induced lipid peroxidation was significantly inhibited by pyruvate treatment. These beneficial cardioprotective effects translated into significant improvement in MAP. Histopathological examination and restored specific myocardial injury marker CK-MB isoenzyme activity further confirmed protective effects of pyruvate. In conclusion, our study has demonstrated that the beneficial effect of pyruvate likely results from improved MAP and suppression of oxidative stress.

Original languageEnglish
Pages (from-to)38-44
Number of pages7
JournalLife Sciences
Volume79
Issue number1
DOIs
Publication statusPublished - May 30 2006
Externally publishedYes

Keywords

  • Cardioprotection
  • Ischemia and reperfusion
  • Myocardial infarction
  • Pyruvate

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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