Quality of Life and Anxiety of Adolescents With Cancer and Their Parents: Neurodevelopmental Implications in Adolescence

Kalliopi Megari; Dimitra V Katsarou; Evangelos Mantsos; Vasiliki Miliadi; Elina Kosmidou; Agathi Argyriadi; Soultana Papadopoulou; Alexandros Argyriadis; Eugenia  I Toki; Maria Sofologi

doi:10.1002/jdn.70040

Quality of Life and Anxiety of Adolescents With Cancer and Their Parents: Neurodevelopmental Implications in Adolescence

Kalliopi Megari
, Dimitra V Katsarou
, Evangelos Mantsos
, Vasiliki Miliadi
, Elina Kosmidou
, Agathi Argyriadi
, Soultana Papadopoulou
, Alexandros Argyriadis
, Eugenia I Toki
, Maria Sofologi

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Background: Cancer is one of the most lethal chronic diseases, which has been the reason for the majority of losses of lives globally. Adolescents with cancer experience a lower quality of life compared to both their healthy peers and adult patients. Methods: In the present study, 237 adolescents and 460 parents were evaluated with measures of quality of life and anxiety. Results: All patients showed lower performance on QoL and increased performance on anxiety measures. Regarding parents' QoL, although parents of all groups had low performance on all measures, parents of adolescents with leukaemia experience poor quality of life and increased levels of anxiety. Conclusion: Adolescents and young adults with cancer are going through a turbulent period of their lives, not only due to their diagnosis and treatment process but also due to the physical and psychosocial changes and neurodevelopmental consequences of paediatric cancer and its treatment in adolescence.

Original language	English
Article number	e70040
Journal	International Journal of Developmental Neuroscience
Volume	85
Issue number	5
DOIs	https://doi.org/10.1002/jdn.70040
Publication status	Published - Aug 2025
Externally published	Yes

Keywords

adolescents
anxiety
cancer
neurodevelopmental implications
parents
quality of life

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Megari, K., Katsarou, DV., Mantsos, E., Miliadi, V., Kosmidou, E., Argyriadi, A., Papadopoulou, S., Argyriadis, A., Toki, E. I., & Sofologi, M. (2025). Quality of Life and Anxiety of Adolescents With Cancer and Their Parents: Neurodevelopmental Implications in Adolescence. International Journal of Developmental Neuroscience, 85(5), Article e70040. https://doi.org/10.1002/jdn.70040

Megari, K, Katsarou, DV, Mantsos, E, Miliadi, V, Kosmidou, E, Argyriadi, A, Papadopoulou, S, Argyriadis, A, Toki, EI & Sofologi, M 2025, 'Quality of Life and Anxiety of Adolescents With Cancer and Their Parents: Neurodevelopmental Implications in Adolescence', International Journal of Developmental Neuroscience, vol. 85, no. 5, e70040. https://doi.org/10.1002/jdn.70040

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abstract = "Background: Cancer is one of the most lethal chronic diseases, which has been the reason for the majority of losses of lives globally. Adolescents with cancer experience a lower quality of life compared to both their healthy peers and adult patients. Methods: In the present study, 237 adolescents and 460 parents were evaluated with measures of quality of life and anxiety. Results: All patients showed lower performance on QoL and increased performance on anxiety measures. Regarding parents' QoL, although parents of all groups had low performance on all measures, parents of adolescents with leukaemia experience poor quality of life and increased levels of anxiety. Conclusion: Adolescents and young adults with cancer are going through a turbulent period of their lives, not only due to their diagnosis and treatment process but also due to the physical and psychosocial changes and neurodevelopmental consequences of paediatric cancer and its treatment in adolescence.",

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author = "Kalliopi Megari and Dimitra V Katsarou and Evangelos Mantsos and Vasiliki Miliadi and Elina Kosmidou and Agathi Argyriadi and Soultana Papadopoulou and Alexandros Argyriadis and Toki, \{Eugenia I\} and Maria Sofologi",

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T2 - Neurodevelopmental Implications in Adolescence

AU - Megari, Kalliopi

AU - Katsarou, Dimitra V

AU - Mantsos, Evangelos

AU - Miliadi, Vasiliki

AU - Kosmidou, Elina

AU - Argyriadi, Agathi

AU - Papadopoulou, Soultana

AU - Argyriadis, Alexandros

AU - Toki, Eugenia I

AU - Sofologi, Maria

PY - 2025/8

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N2 - Background: Cancer is one of the most lethal chronic diseases, which has been the reason for the majority of losses of lives globally. Adolescents with cancer experience a lower quality of life compared to both their healthy peers and adult patients. Methods: In the present study, 237 adolescents and 460 parents were evaluated with measures of quality of life and anxiety. Results: All patients showed lower performance on QoL and increased performance on anxiety measures. Regarding parents' QoL, although parents of all groups had low performance on all measures, parents of adolescents with leukaemia experience poor quality of life and increased levels of anxiety. Conclusion: Adolescents and young adults with cancer are going through a turbulent period of their lives, not only due to their diagnosis and treatment process but also due to the physical and psychosocial changes and neurodevelopmental consequences of paediatric cancer and its treatment in adolescence.

AB - Background: Cancer is one of the most lethal chronic diseases, which has been the reason for the majority of losses of lives globally. Adolescents with cancer experience a lower quality of life compared to both their healthy peers and adult patients. Methods: In the present study, 237 adolescents and 460 parents were evaluated with measures of quality of life and anxiety. Results: All patients showed lower performance on QoL and increased performance on anxiety measures. Regarding parents' QoL, although parents of all groups had low performance on all measures, parents of adolescents with leukaemia experience poor quality of life and increased levels of anxiety. Conclusion: Adolescents and young adults with cancer are going through a turbulent period of their lives, not only due to their diagnosis and treatment process but also due to the physical and psychosocial changes and neurodevelopmental consequences of paediatric cancer and its treatment in adolescence.

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KW - anxiety

KW - cancer

KW - neurodevelopmental implications

KW - parents

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Quality of Life and Anxiety of Adolescents With Cancer and Their Parents: Neurodevelopmental Implications in Adolescence

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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