@article{21299be4602440d2b13174c70f6337b8,
title = "Quantum dots: The cutting-edge nanotheranostics in brain cancer management",
abstract = "Quantum dots (QDs) are semiconductor nanocrystals possessing unique optoelectrical properties in that they can emit light energy of specific tunable wavelengths when excited by photons. They are gaining attention nowadays owing to their all-around ability to allow high-quality bio-imaging along with targeted drug delivery. The most lethal central nervous system (CNS) disorders are brain cancers or malignant brain tumors. CNS is guarded by the blood-brain barrier which poses a selective blockade toward drug delivery into the brain. QDs have displayed strong potential to deliver therapeutic agents into the brain successfully. Their bio-imaging capability due to photoluminescence and specific targeting ability through the attachment of ligand biomolecules make them preferable clinical tools for coming times. Biocompatible QDs are emerging as nanotheranostic tools to identify/diagnose and selectively kill cancer cells. The current review focuses on QDs and associated nanoformulations as potential futuristic clinical aids in the continuous battle against brain cancer.",
keywords = "Bio-imaging, Blood-brain barrier, Brain cancer, Nanotheranostics, Photodynamic therapy, Quantum dots",
author = "Pratik Chakraborty and Das, {Sabya Sachi} and Abhijit Dey and Apala Chakraborty and Chiranjib Bhattacharyya and Ramesh Kandimalla and Biswajit Mukherjee and Gopalakrishnan, {Abilash Valsala} and Singh, {Sandeep Kumar} and Shubham Kant and Parma Nand and Shreesh Ojha and Pravir Kumar and Jha, {Niraj Kumar} and Jha, {Saurabh Kumar} and Saikat Dewanjee",
note = "Funding Information: The authors are thankful to the Council of Scientific and Industrial Research , India for awarding a research project (grant number 02(0275)/16/EMR-II dated 06.12.2016) to Saikat Dewanjee. Jadavpur University, India is acknowledged for awarding the State Government Research Fellowship to PC (Ref no: R-11/13/20 dated 22.01.2020). Saikat Dewanjee also wants to acknowledge his colleague, Dr. Ketousetuo Kuotsu, Associate Professor, Department of Pharmaceutical Technology, Jadavpur University, India to give the idea to write a review on this topic. Finally, the authors would like to express their gratitude to the editor and reviewers for their insightful comments and criticism, which contributed to improving the scientific calibre of this review. Funding Information: The authors are thankful to the Council of Scientific and Industrial Research, India for awarding a research project (grant number 02(0275)/16/EMR-II dated 06.12.2016) to Saikat Dewanjee. Jadavpur University, India is acknowledged for awarding the State Government Research Fellowship to PC (Ref no: R-11/13/20 dated 22.01.2020). Saikat Dewanjee also wants to acknowledge his colleague, Dr. Ketousetuo Kuotsu, Associate Professor, Department of Pharmaceutical Technology, Jadavpur University, India to give the idea to write a review on this topic. Finally, the authors would like to express their gratitude to the editor and reviewers for their insightful comments and criticism, which contributed to improving the scientific calibre of this review. Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",
year = "2022",
month = oct,
doi = "10.1016/j.jconrel.2022.08.047",
language = "English",
volume = "350",
pages = "698--715",
journal = "Journal of Controlled Release",
issn = "0168-3659",
publisher = "Elsevier",
}