TY - JOUR
T1 - Rapid progression to disease in african sex workers with human immunodeficiency virus type 1 infection
AU - Anzala, Omu A.
AU - Nagelkerke, Nico J.D.
AU - Bwayo, Job J.
AU - Holton, Donna
AU - Moses, Stephen
AU - Ngugi, Elizabeth N.
AU - Ndinya-Achola, Jackoniah O.
AU - Plummer, Francis A.
N1 - Funding Information:
Received 4 June 1994; revised 19 August 1994. Grant support: Rockefeller Foundation; Special Program grant from Medical Research Council ofCanada (MRC SP27). FA.P. is an MRC Scientist.
PY - 1995/3
Y1 - 1995/3
N2 - From a cohort of female sex workers in Nairobi, Kenya, 163 women were observed to seroconvert to human immunodeficiency virus type 1 (HIV-1) and followed to study progression to HIV-I-related disease. The effect of several covariables on disease progression was studied using a Weibull proportional hazards model. The Weibull survival model was fitted to the observed incubation times. Estimates of the median duration to CDC stage IV-A and IV-C disease were 3.5 and 4.4 years, respectively. Condom use before seroconversion was associated with a reduced risk of CDC stage IV-A disease (relative risk =.64, P ≤.05). The incubation time of HIV-I-related disease is extremely short in this population.
AB - From a cohort of female sex workers in Nairobi, Kenya, 163 women were observed to seroconvert to human immunodeficiency virus type 1 (HIV-1) and followed to study progression to HIV-I-related disease. The effect of several covariables on disease progression was studied using a Weibull proportional hazards model. The Weibull survival model was fitted to the observed incubation times. Estimates of the median duration to CDC stage IV-A and IV-C disease were 3.5 and 4.4 years, respectively. Condom use before seroconversion was associated with a reduced risk of CDC stage IV-A disease (relative risk =.64, P ≤.05). The incubation time of HIV-I-related disease is extremely short in this population.
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U2 - 10.1093/infdis/171.3.686
DO - 10.1093/infdis/171.3.686
M3 - Article
C2 - 7876618
AN - SCOPUS:0028987116
SN - 0022-1899
VL - 171
SP - 686
EP - 689
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -