Rapid progression to disease in african sex workers with human immunodeficiency virus type 1 infection

Omu A. Anzala; Nico J.D. Nagelkerke; Job J. Bwayo; Donna Holton; Stephen Moses; Elizabeth N. Ngugi; Jackoniah O. Ndinya-Achola; Francis A. Plummer

doi:10.1093/infdis/171.3.686

Rapid progression to disease in african sex workers with human immunodeficiency virus type 1 infection

Omu A. Anzala
, Nico J.D. Nagelkerke
, Job J. Bwayo
, Donna Holton
, Stephen Moses
, Elizabeth N. Ngugi
, Jackoniah O. Ndinya-Achola
, Francis A. Plummer

Research output: Contribution to journal › Article › peer-review

122 Citations (Scopus)

Abstract

From a cohort of female sex workers in Nairobi, Kenya, 163 women were observed to seroconvert to human immunodeficiency virus type 1 (HIV-1) and followed to study progression to HIV-I-related disease. The effect of several covariables on disease progression was studied using a Weibull proportional hazards model. The Weibull survival model was fitted to the observed incubation times. Estimates of the median duration to CDC stage IV-A and IV-C disease were 3.5 and 4.4 years, respectively. Condom use before seroconversion was associated with a reduced risk of CDC stage IV-A disease (relative risk =.64, P ≤.05). The incubation time of HIV-I-related disease is extremely short in this population.

Original language	English
Pages (from-to)	686-689
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	171
Issue number	3
DOIs	https://doi.org/10.1093/infdis/171.3.686
Publication status	Published - Mar 1995
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Access to Document

10.1093/infdis/171.3.686

Cite this

@article{d87d5097465b4c4db3bf644e5ebfbd6b,

title = "Rapid progression to disease in african sex workers with human immunodeficiency virus type 1 infection",

abstract = "From a cohort of female sex workers in Nairobi, Kenya, 163 women were observed to seroconvert to human immunodeficiency virus type 1 (HIV-1) and followed to study progression to HIV-I-related disease. The effect of several covariables on disease progression was studied using a Weibull proportional hazards model. The Weibull survival model was fitted to the observed incubation times. Estimates of the median duration to CDC stage IV-A and IV-C disease were 3.5 and 4.4 years, respectively. Condom use before seroconversion was associated with a reduced risk of CDC stage IV-A disease (relative risk =.64, P ≤.05). The incubation time of HIV-I-related disease is extremely short in this population.",

author = "Anzala, \{Omu A.\} and Nagelkerke, \{Nico J.D.\} and Bwayo, \{Job J.\} and Donna Holton and Stephen Moses and Ngugi, \{Elizabeth N.\} and Ndinya-Achola, \{Jackoniah O.\} and Plummer, \{Francis A.\}",

note = "Funding Information: Received 4 June 1994; revised 19 August 1994. Grant support: Rockefeller Foundation; Special Program grant from Medical Research Council ofCanada (MRC SP27). FA.P. is an MRC Scientist.",

year = "1995",

month = mar,

doi = "10.1093/infdis/171.3.686",

language = "English",

volume = "171",

pages = "686--689",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "3",

}

TY - JOUR

T1 - Rapid progression to disease in african sex workers with human immunodeficiency virus type 1 infection

AU - Anzala, Omu A.

AU - Nagelkerke, Nico J.D.

AU - Bwayo, Job J.

AU - Holton, Donna

AU - Moses, Stephen

AU - Ngugi, Elizabeth N.

AU - Ndinya-Achola, Jackoniah O.

AU - Plummer, Francis A.

N1 - Funding Information: Received 4 June 1994; revised 19 August 1994. Grant support: Rockefeller Foundation; Special Program grant from Medical Research Council ofCanada (MRC SP27). FA.P. is an MRC Scientist.

PY - 1995/3

Y1 - 1995/3

N2 - From a cohort of female sex workers in Nairobi, Kenya, 163 women were observed to seroconvert to human immunodeficiency virus type 1 (HIV-1) and followed to study progression to HIV-I-related disease. The effect of several covariables on disease progression was studied using a Weibull proportional hazards model. The Weibull survival model was fitted to the observed incubation times. Estimates of the median duration to CDC stage IV-A and IV-C disease were 3.5 and 4.4 years, respectively. Condom use before seroconversion was associated with a reduced risk of CDC stage IV-A disease (relative risk =.64, P ≤.05). The incubation time of HIV-I-related disease is extremely short in this population.

AB - From a cohort of female sex workers in Nairobi, Kenya, 163 women were observed to seroconvert to human immunodeficiency virus type 1 (HIV-1) and followed to study progression to HIV-I-related disease. The effect of several covariables on disease progression was studied using a Weibull proportional hazards model. The Weibull survival model was fitted to the observed incubation times. Estimates of the median duration to CDC stage IV-A and IV-C disease were 3.5 and 4.4 years, respectively. Condom use before seroconversion was associated with a reduced risk of CDC stage IV-A disease (relative risk =.64, P ≤.05). The incubation time of HIV-I-related disease is extremely short in this population.

UR - https://www.scopus.com/pages/publications/0028987116

UR - https://www.scopus.com/pages/publications/0028987116#tab=citedBy

U2 - 10.1093/infdis/171.3.686

DO - 10.1093/infdis/171.3.686

M3 - Article

C2 - 7876618

AN - SCOPUS:0028987116

SN - 0022-1899

VL - 171

SP - 686

EP - 689

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 3

ER -

Rapid progression to disease in african sex workers with human immunodeficiency virus type 1 infection

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this