TY - JOUR
T1 - Recent advancements on the synthesis and biological significance of pipecolic acid and its derivatives
AU - Al-Rooqi, Munirah M.
AU - Ullah Mughal, Ehsan
AU - Raja, Qandeel Alam
AU - Obaid, Rami J.
AU - Sadiq, Amina
AU - Naeem, Nafeesa
AU - Qurban, Jihan
AU - Asghar, Basim H.
AU - Moussa, Ziad
AU - Ahmed, Saleh A.
N1 - Funding Information:
The authors would like to acknowledge the Deanship of Scientific Research at Umm Al-Qura University, for supporting this work by Grant code: 22UQU4331342DSR02, the authors are highly thankful to the Higher Education Commission of Pakistan (HEC) for providing financial assistance under Project No. ( NRPU-15800 ). Dr. Ziad Moussa is grateful to the United Arab Emirates University (UAEU) of Al-Ain and the Research Office for supporting the research developed in his laboratory (Grant no. G00003291 ).
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/11/15
Y1 - 2022/11/15
N2 - Pipecolic acids are cyclic non-protein amino acids serving as precursors for the biosynthesis of biological metabolites. Structurally, the six-membered cyclic motif consists of five-carbons and one nitrogen atom. The pipecolic acid (Pip) nucleus is present as a central structural component in many biological systems. It is a cyclic amino acid derived from L-lysine which has gained interest in the recent years within the pharmaceutical and chemical industries. This review focuses on three aspects of Pip. The first part provides detailed introduction and synthesis of Pip, while the second part describes the incorporation of Pip into peptides and lastly, in the third part, the biological applications of Pip are discussed. Herein, we have presented a detailed review on Pip and combined, for the first time, peptides of Pip and biological activities of Pip and its derivatives in one frame.
AB - Pipecolic acids are cyclic non-protein amino acids serving as precursors for the biosynthesis of biological metabolites. Structurally, the six-membered cyclic motif consists of five-carbons and one nitrogen atom. The pipecolic acid (Pip) nucleus is present as a central structural component in many biological systems. It is a cyclic amino acid derived from L-lysine which has gained interest in the recent years within the pharmaceutical and chemical industries. This review focuses on three aspects of Pip. The first part provides detailed introduction and synthesis of Pip, while the second part describes the incorporation of Pip into peptides and lastly, in the third part, the biological applications of Pip are discussed. Herein, we have presented a detailed review on Pip and combined, for the first time, peptides of Pip and biological activities of Pip and its derivatives in one frame.
KW - Biological applications
KW - Non-protein amino acids
KW - Peptide's formation
KW - Pipecolic acid
KW - Synthesis
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U2 - 10.1016/j.molstruc.2022.133719
DO - 10.1016/j.molstruc.2022.133719
M3 - Review article
AN - SCOPUS:85134615978
SN - 0022-2860
VL - 1268
JO - Journal of Molecular Structure
JF - Journal of Molecular Structure
M1 - 133719
ER -