Recent advancements on the synthesis and biological significance of pipecolic acid and its derivatives

Munirah M. Al-Rooqi, Ehsan Ullah Mughal, Qandeel Alam Raja, Rami J. Obaid, Amina Sadiq, Nafeesa Naeem, Jihan Qurban, Basim H. Asghar, Ziad Moussa, Saleh A. Ahmed

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)


Pipecolic acids are cyclic non-protein amino acids serving as precursors for the biosynthesis of biological metabolites. Structurally, the six-membered cyclic motif consists of five-carbons and one nitrogen atom. The pipecolic acid (Pip) nucleus is present as a central structural component in many biological systems. It is a cyclic amino acid derived from L-lysine which has gained interest in the recent years within the pharmaceutical and chemical industries. This review focuses on three aspects of Pip. The first part provides detailed introduction and synthesis of Pip, while the second part describes the incorporation of Pip into peptides and lastly, in the third part, the biological applications of Pip are discussed. Herein, we have presented a detailed review on Pip and combined, for the first time, peptides of Pip and biological activities of Pip and its derivatives in one frame.

Original languageEnglish
Article number133719
JournalJournal of Molecular Structure
Publication statusPublished - Nov 15 2022


  • Biological applications
  • Non-protein amino acids
  • Peptide's formation
  • Pipecolic acid
  • Synthesis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Inorganic Chemistry


Dive into the research topics of 'Recent advancements on the synthesis and biological significance of pipecolic acid and its derivatives'. Together they form a unique fingerprint.

Cite this