Reduction of T2 relaxation rates due to large volume fractions of magnetic nanoparticles for all motional regimes

Bashar Issa

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Abstract: The effect of high volume fraction of magnetic nanoparticles (MNP) on Magnetic Resonance Imaging (MRI) transverse relaxation rates (R2 = 1/T2 and R2* = 1/T2*) is investigated using Monte Carlo (MC) simulations. Theoretical models assume that particles occupy a small volume fraction of the sample space. Results presented in this work show that models based on both motional averaged (MAR) and static dephasing (SDR) regimes respectively underestimate and overestimate relaxation rates at large volume fractions. Furthermore, both R2* and R2* become echo-time dependent. This suggests that diffusion is involved with larger echo-times producing smaller relaxation rates due to better averaging of the magnetic field gradients. Findings emphasize the need for the models to be modified to take account of high particle concentration especially important for application involving clustering and trapping of nanoparticles inside cells. This is important in order to improve the design process of MNP Contrast Agents.

Original languageEnglish
Article number101
JournalApplied Sciences (Switzerland)
Volume8
Issue number1
DOIs
Publication statusPublished - Jan 11 2018

Keywords

  • Contrast agent
  • MAR
  • MRI
  • Magnetic nanoparticles
  • Monte Carlo
  • SDR
  • T2

ASJC Scopus subject areas

  • General Materials Science
  • Instrumentation
  • General Engineering
  • Process Chemistry and Technology
  • Computer Science Applications
  • Fluid Flow and Transfer Processes

Fingerprint

Dive into the research topics of 'Reduction of T2 relaxation rates due to large volume fractions of magnetic nanoparticles for all motional regimes'. Together they form a unique fingerprint.

Cite this