TY - JOUR
T1 - Regioselective synthesis of new pyrimidine derivatives using organolithium reagents
AU - Abdou, Ibrahim M.
PY - 2006/12
Y1 - 2006/12
N2 - 2,4-Dichloro-6-phenylpyrimidine (3) and 2-chloro-4-(1′, 3′dithian2′-yl)pyrimidine (7) were prepared using organolithium reagents. Nucleophilic attack on pyrimidines 1, 3 and 9 using N-methylpiperazine was shown to be highly regioselective, favouring the formation of C-4 substituted products. Reaction of 7 with N,N-dimethylethylenediamine afforded 8 exclusively.
AB - 2,4-Dichloro-6-phenylpyrimidine (3) and 2-chloro-4-(1′, 3′dithian2′-yl)pyrimidine (7) were prepared using organolithium reagents. Nucleophilic attack on pyrimidines 1, 3 and 9 using N-methylpiperazine was shown to be highly regioselective, favouring the formation of C-4 substituted products. Reaction of 7 with N,N-dimethylethylenediamine afforded 8 exclusively.
KW - Nucleophilic substitution
KW - Organolithium
KW - Pyrimidines
KW - Regioselectivity
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U2 - 10.3184/030823406780199686
DO - 10.3184/030823406780199686
M3 - Article
AN - SCOPUS:33846685334
SN - 0308-2342
SP - 785
EP - 787
JO - Journal of Chemical Research
JF - Journal of Chemical Research
IS - 12
ER -