Regioselective synthesis of new pyrimidine derivatives using organolithium reagents

Ibrahim M. Abdou

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


2,4-Dichloro-6-phenylpyrimidine (3) and 2-chloro-4-(1′, 3′dithian2′-yl)pyrimidine (7) were prepared using organolithium reagents. Nucleophilic attack on pyrimidines 1, 3 and 9 using N-methylpiperazine was shown to be highly regioselective, favouring the formation of C-4 substituted products. Reaction of 7 with N,N-dimethylethylenediamine afforded 8 exclusively.

Original languageEnglish
Pages (from-to)785-787
Number of pages3
JournalJournal of Chemical Research
Issue number12
Publication statusPublished - Dec 2006


  • Nucleophilic substitution
  • Organolithium
  • Pyrimidines
  • Regioselectivity

ASJC Scopus subject areas

  • General Chemistry


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