Abstract
2,4-Dichloro-6-phenylpyrimidine (3) and 2-chloro-4-(1′, 3′dithian2′-yl)pyrimidine (7) were prepared using organolithium reagents. Nucleophilic attack on pyrimidines 1, 3 and 9 using N-methylpiperazine was shown to be highly regioselective, favouring the formation of C-4 substituted products. Reaction of 7 with N,N-dimethylethylenediamine afforded 8 exclusively.
| Original language | English |
|---|---|
| Pages (from-to) | 785-787 |
| Number of pages | 3 |
| Journal | Journal of Chemical Research - Part S |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 2006 |
Keywords
- Nucleophilic substitution
- Organolithium
- Pyrimidines
- Regioselectivity
ASJC Scopus subject areas
- General Chemistry
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