Reliability of fasting plasma alkylresorcinol metabolites concentrations measured 4 months apart

J. Montonen, R. Landberg, A. Kamal-Eldin, P. Man, H. Boeing, A. Steffen, T. Pischon

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Alkylresorcinols (AR) have been suggested as specific dietary biomarkers of whole-grain wheat and rye intake. AR are metabolised to 3,5-dihydroxybenzoic acid (DHBA) and 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), which have longer apparent half-lives and were recently proposed to better reflect long-term whole-grain consumption than the intact AR. The objective of this study was to analyse the reliabilityexpressed by the intraclass correlation coefficient (ICC)of AR metabolite concentrations among 100 participants from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study who provided two fasting plasma samples 4 months apart. DHBA and DHPPA concentrations were not significantly different between the first and second measurement over the 4-month period (P0.05). The ICC was 0.32 (95% confidence interval (CI)0.13-0.49) for DHBA and 0.37 (95%CI0.19-0.53) for DHPPA. These results suggest that AR metabolites cannot be considered to be better biomarkers of whole-grain wheat and rye intake than the intact AR in fasting plasma (ICC0.42).

Original languageEnglish
Pages (from-to)968-970
Number of pages3
JournalEuropean Journal of Clinical Nutrition
Issue number8
Publication statusPublished - Aug 2012
Externally publishedYes


  • DHBA
  • alkylresorcinols
  • biomarker
  • reliability
  • whole-grain

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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