Abstract
Alkylresorcinols (AR) have been suggested as specific dietary biomarkers of whole-grain wheat and rye intake. AR are metabolised to 3,5-dihydroxybenzoic acid (DHBA) and 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), which have longer apparent half-lives and were recently proposed to better reflect long-term whole-grain consumption than the intact AR. The objective of this study was to analyse the reliabilityexpressed by the intraclass correlation coefficient (ICC)of AR metabolite concentrations among 100 participants from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study who provided two fasting plasma samples 4 months apart. DHBA and DHPPA concentrations were not significantly different between the first and second measurement over the 4-month period (P0.05). The ICC was 0.32 (95% confidence interval (CI)0.13-0.49) for DHBA and 0.37 (95%CI0.19-0.53) for DHPPA. These results suggest that AR metabolites cannot be considered to be better biomarkers of whole-grain wheat and rye intake than the intact AR in fasting plasma (ICC0.42).
Original language | English |
---|---|
Pages (from-to) | 968-970 |
Number of pages | 3 |
Journal | European Journal of Clinical Nutrition |
Volume | 66 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 2012 |
Externally published | Yes |
Keywords
- DHBA
- DHPPA
- alkylresorcinols
- biomarker
- reliability
- whole-grain
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics