Reliability of Machine Learning in Eliminating Data Redundancy of Radiomics and Reflecting Pathophysiology in COVID-19 Pneumonia: Impact of CT Reconstruction Kernels on Accuracy

  • Yauhen Statsenko
  • , Tetiana Habuza
  • , Tatsiana Talako
  • , Tetiana Kurbatova
  • , Gillian Lylian Simiyu
  • , Darya Smetanina
  • , Juana Sido
  • , Dana Sharif Qandil
  • , Sarah Meribout
  • , Juri G. Gelovani
  • , Klaus Friedrich Neidl
  • , Taleb M. Almansoori
  • , Fatmah Al Zahmi
  • , Tom Loney
  • , Anthony Bedson
  • , Nerissa Naidoo
  • , Alireza Dehdashtian
  • , Milos Ljubisavljevic
  • , Jamal Al Koteesh
  • , Karuna M. Das

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Background: Radiomical data are redundant but they might serve as a tool for lung quantitative assessment reflecting disease severity and actual physiological status of COVID-19 patients. Objective: Test the effectiveness of machine learning in eliminating data redundancy of radiomics and reflecting pathophysiologic changes in patients with COVID-19 pneumonia. Methods: We analyzed 605 cases admitted to Al Ain Hospital from 24 February to 1 July, 2020. They met the following inclusion criteria: age ≥ 18 years; inpatient admission; PCR positive for SARS-CoV-2; lung CT available at PACS. We categorized cases into 4 classes: mild <5% of pulmonary parenchymal involvement, moderate - 5-24%, severe - 25-49%, and critical ≥50 %. We used CT scans to build regression models predicting the oxygenation level, respiratory and cardiovascular functioning. Results: Radiomical findings are a reliable source of information to assess the functional status of patients with COVID-19.

Original languageEnglish
Pages (from-to)120901-120921
Number of pages21
JournalIEEE Access
Volume10
DOIs
Publication statusPublished - 2022

Keywords

  • Blended machine learning model
  • COVID-19
  • SARC-CoV-2
  • functional outcomes
  • lung structural changes
  • pneumonia
  • radiomics
  • structure-function association

ASJC Scopus subject areas

  • General Computer Science
  • General Materials Science
  • General Engineering

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