Remodelling of the neuromuscular junction after subtotal disuse

M. A. Fahim; N. Robbins

doi:10.1016/0006-8993(86)90039-9

Remodelling of the neuromuscular junction after subtotal disuse

M. A. Fahim
, N. Robbins

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Within 5 days after reduction of activity of the rat soleus muscle, there was remodelling of the neuromuscular junction. Post-synaptic clefts were shorter, wider, and flatter, whereas nerve terminals showed sprouting and longitudinal distortion. The results, which differ from those found after denervation or total disuse, reveal the plasticity of the mature neuromuscular synapse.

Original language	English
Pages (from-to)	353-356
Number of pages	4
Journal	Brain Research
Volume	383
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(86)90039-9
Publication status	Published - Sept 24 1986
Externally published	Yes

Keywords

Muscle disuse
Muscle innervation
Nerve terminal
Neuromuscular junction
Neuromuscular remodelling
Synaptic plasticity

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(86)90039-9

Cite this

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title = "Remodelling of the neuromuscular junction after subtotal disuse",

abstract = "Within 5 days after reduction of activity of the rat soleus muscle, there was remodelling of the neuromuscular junction. Post-synaptic clefts were shorter, wider, and flatter, whereas nerve terminals showed sprouting and longitudinal distortion. The results, which differ from those found after denervation or total disuse, reveal the plasticity of the mature neuromuscular synapse.",

keywords = "Muscle disuse, Muscle innervation, Nerve terminal, Neuromuscular junction, Neuromuscular remodelling, Synaptic plasticity",

author = "Fahim, \{M. A.\} and N. Robbins",

note = "Funding Information: This work was supported by Grants AG00795 and NS18694 from the National Institute of Health and by Grant BNS-8319639 from the National Science Foundation. The excellent technical contribution of Valerie Young is gratefully acknowledged.",

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AU - Fahim, M. A.

AU - Robbins, N.

N1 - Funding Information: This work was supported by Grants AG00795 and NS18694 from the National Institute of Health and by Grant BNS-8319639 from the National Science Foundation. The excellent technical contribution of Valerie Young is gratefully acknowledged.

PY - 1986/9/24

Y1 - 1986/9/24

N2 - Within 5 days after reduction of activity of the rat soleus muscle, there was remodelling of the neuromuscular junction. Post-synaptic clefts were shorter, wider, and flatter, whereas nerve terminals showed sprouting and longitudinal distortion. The results, which differ from those found after denervation or total disuse, reveal the plasticity of the mature neuromuscular synapse.

AB - Within 5 days after reduction of activity of the rat soleus muscle, there was remodelling of the neuromuscular junction. Post-synaptic clefts were shorter, wider, and flatter, whereas nerve terminals showed sprouting and longitudinal distortion. The results, which differ from those found after denervation or total disuse, reveal the plasticity of the mature neuromuscular synapse.

KW - Muscle disuse

KW - Muscle innervation

KW - Nerve terminal

KW - Neuromuscular junction

KW - Neuromuscular remodelling

KW - Synaptic plasticity

UR - https://www.scopus.com/pages/publications/0022995521

UR - https://www.scopus.com/pages/publications/0022995521#tab=citedBy

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SN - 0006-8993

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EP - 356

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

Remodelling of the neuromuscular junction after subtotal disuse

Abstract

Keywords

ASJC Scopus subject areas

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